844446-53-3Relevant academic research and scientific papers
Lipase-promoted access to phenolic herbertane-type sesquiterpenes: (+)-1,14-Herbertenediol, (-)-α-herbertenol, (-)-herbertenediol and their enantiomers
Acherar, Samir,Audran, Gerard,Fotiadu, Frederic,Monti, Honore
, p. 5092 - 5099 (2007/10/03)
An enantioselective synthesis of (+)-1,14-herbertenediol, and a formal enantioselective synthesis of (-)-α-herbertenol and (-)-herbertenediol, employing a lipase-promoted and a key stereoselective alkylation of a cyclopentane unit based methodology, are described. Molecular mechanics considerations that could account for the major role played by the substitution pattern of the benzene nucleus in the herbertane framework in comparison with those of the cuparane framework are described. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.
