84446-21-9

Upstream product

• 6298-19-7 2-chloro-3-aminopyridine 
• 609-65-4 o-chlorobenzoyl chloride 

Downstream Products

• 77712-87-9 2-(2'-chlorophenyl)imidazolo<5,4-b>pyridine 
• 88369-51-1 2-methyl-3-(2'-pyridon-3'-yl)quinazolin-4-one 
• 84446-16-2 3-(2'-chlorobenzoyl)amino-2-chloropyridine 1-oxide 
• 52334-72-2 3-(2'-chlorobenzoyl)aminopyrid-2-one 
• 956-30-9 2-amino-N-(2-chloropyridin-3-yl)benzamide 
• 52334-10-8 2-(2-chloro-phenyl)oxazolo<5,4-b>pyridine 
• 88369-30-6 3-(2'-chlorobenzoyl)amino-2-methoxypyridine 
• 88369-28-2 3-(2'-chlorobenzoyl)aminothiopyrid-2-one 
• 88369-29-3 2-(2'-chlorophenyl)thiazolo<5,4-b>pyridine 
• 20091-81-0 2-methyl-3-(2'-chloropyrid-3'-yl)quinazolin-4-one 
• 28797-61-7 pirenzepine 
• 885-70-1 5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one 
• 79276-55-4 5,11-dihydro-11-<(2'-methylimidazo-1'-yl)-acetyl>-6H-pyrido<2,3-b><1,4>benzodiazepin-6-one 
• 79276-54-3 5,11-dihydro-11-<(imidazo-1'-yl)-acetyl>-6H-pyrido<2,3-b><1,4>benzodiazepin-6-one 

Relevant academic research and scientific papers

A general and efficient synthesis of 2-substituted oxazolopyridines

Starting from commercially available halonitropyridines and haloaminopyridines, 2-substituted-oxazolo[5,4-b]pyridines, and 2-aryl-oxazolo[4,5-b]pyridines were synthesized in good yields by using a Cu(I)-mediated cyclization of halopyridylamides as a key step. Georg Thieme Verlag Stuttgart.

Process for the synthesis of oxazolopyridine compounds

Process for the synthesis of compounds of formula (I): STR1 their pyridinium salts and N-oxides, in which formula: the nitrogen of the pyridine ring is situated in the α-, β-, γ- or δ-position with respect to the ring junction; R1 represents a halogen, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkoxy or a nitro, substituted or unsubstituted amino, phenyl or cyano group; 0≤m≤2; R2 represents a lower alkyl or cycloalkyl group, a 5- or 6-membered heterocycle containing 1 or 2 hetero atoms, substituted or otherwise, or an aryl group STR2 such that: R3 represents a halogen, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkoxy or a nitro, phenyl, substituted or unsubstituted sulfonyl, cyano, thioalkyl, substituted or unsubstituted amino, substituted or unsubstituted sulfinyl, mercapto, hydroxyl or ester group, 0≤n≤5 employing trimethylsilyl polyphosphate (PPSE) as a cyclization agent and enabling the compounds of formula (I) to be obtained in virtually quantitative yields. The compounds of formula I have anti-inflammatory, analgesic, and antipyretic activity.

A New Convenient Synthesis of 2-Aryl- and 2-Heteroaryloxazolopyridines

Several 2-aryl- and 2-heteroaryloxazolopyridines were synthesized in high yields from 3-(arylcarbonylamino)-2-chloropyridines by heating in the presence of trimethylsilylpolyphosphate ester.

Novel synthesis of 5,11-dihydro-6H-pyrido[2,3-b]-[1,4]-benzodiazepin-6-ones and related studies (1)

5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one (1), a basic intermediate in the preparation of 11-α-aminoacetyl derivatives with important biological activities, has been obtained by a three-step synthesis starting from easily available isatoic anhydride and anhydro ornithine. Some model cyclisation reactions leading to 5-member ring derivatives 10 and 12 instead of 7-member ring analogues of 1, are reported. Easy transformations of the tetrahydro congener of 1, i.e. compound 4 into 19, which actually represents a tetrahedral intermediate in the transformation of 5 into 4, is noticed. Further rearrangement of 19 into spiro compounds 20, and return of the latter into 5 is described.