844470-85-5

Basic information

• Product Name: 1-Propanone, 1-(4-fluorophenyl)-, oxime
• CAS NO: 844470-85-5
• Molecular Formula: C9H10FNO
• Molecular Weight: 167.183
• Mol File: 844470-85-5.mol

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 1-(4-fluorophenyl)-, oxime(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 1-(4-fluorophenyl)-, oxime(844470-85-5)
• EPA Substance Registry System: 1-Propanone, 1-(4-fluorophenyl)-, oxime(844470-85-5)

Safety Data

• Hazardous Substances Data: 844470-85-5(Hazardous Substances Data)

Upstream product

• 456-03-1 1-(4-fluorophenyl)propan-1-one 

Downstream Products

• 1160691-99-5 ethyl 4-(4-fluorophenyl)-4-(hydroxyimino)-3-methyl-2-oxobutanoate 
• 1462328-06-8 4-fluoropropiophenone O-acetyloxime 
• 1609574-68-6 2,6-bis(4-fluorophenyl)-3,5-dimethylpyridine 
• 1522130-55-7 C₁₈H₁₅F₂N 
• 1462327-98-5 dimethyl 5-(4-fluorophenyl)-4-methyl-1H-pyrrole-2,3-dicarboxylate 
• 1401548-38-6 1-ethyl-6-fluoro-3,4-diphenylisoquinoline 
• 1225220-09-6 (Z)-N-(1-(4-fluorophenyl)prop-1-enyl)acetamide 

Relevant articles and documents

A new route to substituted furocoumarins via copper-catalyzed cyclization between 4-hydroxycoumarins and ketoximes

A new route to substituted furocoumarins via copper-catalyzed cyclization between 4-hydroxycoumarins and ketoximes was developed. CuBr2 exhibited higher activity than other copper salts, affording the desired furocoumarins in high yields. The transformation proceeded readily in the absence of stoichiometric external oxidants. The significance of this synthetic strategy would be (1) the easily available starting materials; (2) low cost catalyst CuBr2; and (3) being without stoichiometric external oxidants. This protocol is complementary to previous approaches in the synthesis of substituted furocoumarins.

Elemental tellurium mediated synthesis of 2-(trifluoromethyl)oxazoles using trifluoroacetic anhydride as reagent

An elemental tellurium mediated synthesis of 2-(trifluoromethyl)oxazoles from the reaction of acetophenone oxime acetates with trifluoroacetic anhydride has been developed. This new tandem cyclization proceeds in good to excellent yields via a SET reduction followed by a 5-endo-trig pathway. Some of the title compounds showed fungicidal and insecticidal activities.

Catalyst free synthesis of mono- and disubstituted pyrimidines from O-acyl oximes

Transition-metal or iodine catalyzed transformations of O-acyl oximes to various N-heterocycles are well established. Herein, we report a catalyst free, oxime carboxylate based, three-component condensation method to access mono- and disubstituted pyrimidines. A broad range of substituted pyrimidines were prepared in moderate to excellent yields. Control experiments reveal that in situ generated formamidine is the key intermediate.

Asymmetric Nitrone Synthesis via Ligand-Enabled Copper-Catalyzed Cope-Type Hydroamination of Cyclopropene with Oxime

We report realization of the first enantioselective Cope-type hydroamination of oximes for asymmetric nitrone synthesis. The ligand promoted asymmetric cyclopropene "hydronitronylation" process employs a Cu-based catalytic system and readily available starting materials, operates under mild conditions and displays broad scope and exceptionally high enantio- and diastereocontrol. Preliminary mechanistic studies corroborate a CuI-catalytic profile featuring an olefin metalla-retro-Cope aminocupration process as the key C-N bond forming event. This conceptually novel reactivity enables the first example of highly enantioselective catalytic nitrone formation process and will likely spur further developments that may significantly expedite chiral nitrone synthesis.

N, N′-dioxide-Cu(OTf)2 complex catalyzed highly enantioselective amination reaction of N-acetyl enamide

The N,N′-dioxide-Cu(OTf)2 complexes were applied in the asymmetric amination reaction of N-acetyl enamides with dialkyl azodicarboxylate, giving the corresponding products in good yields with high enantioselectivities (up to 91% ee). Precursors of vicinal diamine were readily obtained with excellent diastereoselectivities (>95:5) by NaBH4 reduction.

ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS

The present invention relates to novel compounds of formula (I) capable of modulating the stability and/or activity of hypoxia inducible factor (HIF) by inhibiting the activity of at least one HIF hydroxylase enzyme.

QUINOLINE 4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS NEUROKININ 3 (NK-3) RECEPTOR ANTAGONISTS

The invention relates to novel quinoline derivatives, processes for their preparation, pharmaceutical compositions containing them and their use as medicaments particularly in treating disorders of the central nervous system (CNS).