844470-98-0

Upstream product

• 844470-97-9 3-bromomethyl-2-(3-fluoro-phenyl)-quinoline-4-carboxylic acid methyl ester 
• 288-36-8 1 ,2,3-Triazole 
• 288-36-8 1,2,3-triazole 
• 77-78-1 dimethyl sulfate 

Relevant academic research and scientific papers

Nonchromatographic isolation of 2-Alkyl-2H-1,2,3-triazoles in the synthesis of NK3 receptor antagonists

A nonchromatographic isolation of a 2-alkyl-2H-triazole from a 1:1 mixture with the corresponding 1-alkyl-1H isomer was developed in a scalable synthesis of a synthetic intermediate for NK3 receptor antagonists. Based on the fundamental nucleophilicity difference in the isomeric triazoles, this method could be used as a general tactic in the isolation of 2H-triazoles.

QUINOLINE 4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS NEUROKININ 3 (NK-3) RECEPTOR ANTAGONISTS

The invention relates to novel quinoline derivatives, processes for their preparation, pharmaceutical compositions containing them and their use as medicaments particularly in treating disorders of the central nervous system (CNS).