844494-17-3Relevant academic research and scientific papers
Hydrocarbon oxidation vs C-C bond-forming approaches for efficient syntheses of oxygenated molecules
Fraunhoffer, Kenneth J.,Bachovchin, Daniel A.,White, M. Christina
, p. 223 - 226 (2007/10/03)
(Chemical Equation Presented) A hydrocarbon oxidation approach has been applied to the construction of several linear (E)-allylic alcohols that have served as intermediates in the synthesis of natural products and natural product-like molecules. In the original syntheses, these intermediates were constructed using a standard Wittig-type olefination approach. We report here that routes to these same intermediates designed around a hydrocarbon oxidation approach are more efficient both in the total number of functional group manipulations (FGMs) and overall steps, as well as in the overall yield.
