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Relevant academic research and scientific papers

Ruthenium-Catalyzed C-H Functionalization of Benzoic Acids with Allyl Alcohols: A Controlled Reactivity Switch between C-H Alkenylation and C-H Alkylation Pathways

A highly selective and switchable ruthenium-catalyzed ortho C-H alkylation and C-H alkenylation of benzoic acids with allyl alcohols is reported. A complete switch in selectivity is achieved upon tuning the reactivity of the organometallic intermediate in the carboxylate-directed C-H activation to provide access to highly useful motifs such as 2-alkylbenzoic acids and phthalides.

Rh-Catalyzed cascade C-H activation/C-C cleavage/cyclization of carboxylic acids with cyclopropanols

Merging both C-H and C-C activation in a tandem process is a marked challenge. A novel Rh(iii)-catalyzed C-H activation/ring opening C-C cleavage/cyclization of carboxylic acids with cyclopropanols was developed for the synthesis of 3-substituted phthalides andα,β-butenolides. This reaction displays excellent functional group tolerance with respect to both carboxylic acids and cyclopropanols and features relatively mild conditions. Remarkably, the utility of this method was highlighted by the rapid construction of bioactive compounds bearing a 3-substituted phthalide frameworkvialate-stage functionalization.

Ruthenium(II)-Catalyzed Hydrogen Isotope Exchange of Pharmaceutical Drugs by C?H Deuteration and C?H Tritiation

Well-defined ruthenium(II) biscarboxylate complexes enabled selective ortho-deuteration with weakly-coordinating, synthetically useful carboxylic acid with outstanding levels of isotopic labeling. The robust nature of the catalytic system was reflected by

Ruthenium(II)-Catalyzed Decarboxylative C-H Activation: Versatile Routes to meta-Alkenylated Arenes

Ruthenium(II) bis(carboxylate)s proved highly effective for two decarboxylative C-H alkenylation strategies. The decarboxylation proceeded efficiently at rather low temperatures. The unique versatility of the decarboxylative ruthenium(II) catalysis is reflected in the oxidative olefinations with alkenes as well as the redox-neutral hydroarylations of alkynes. Two birds with one Ru: Ruthenium(II) catalysis enabled decarboxylative C-H olefinations by carboxylate assistance at low temperature. It is applicable to both alkenes for oxidative olefinations, as well as alkynes for redox-neutral hydroarylations. Neither silver nor copper salts are required and meta-substituted products can be accessed with this method.

Iridium-catalyzed H/D exchange

The scope and limitation of an iridium-catalysed H/D exchange reaction has been investigated. Our results suggest a general mechanism for specific labelling at aromatic and non-aromatic double bonds by D2O if an electron-donating group is in a 1,4-relation with the carbon where the H/D exchange takes place. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.