844500-06-7Relevant academic research and scientific papers
Discovery and SAR development of thienopyridones: A class of small molecule AMPK activators
Zhao, Gang,Iyengar, Rajesh R.,Judd, Andrew S.,Cool, Barbara,Chiou, William,Kifle, Lemma,Frevert, Ernst,Sham, Hing,Kym, Philip R.
, p. 3254 - 3257 (2008/02/08)
AMP-activated protein kinase (AMPK) is well established as a sensor and regulator of intracellular and whole-body energy metabolism. A high-throughput screen was performed in order to identify chemotypes that are bound by AMPK. A novel thienopyridone comp
Thienopyridones as AMPK activators for the treatment of diabetes and obesity
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Page/Page column 36, (2010/02/10)
The present invention relates to compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, and obesity.
