84454-35-3 Usage
Uses
Used in Pharmaceutical Industry:
BETA-CCB is used as a research compound for studying its effects on the central nervous system and its potential role in the development of anxiety and seizure disorders. Its presence in the brain and its ability to bind to benzodiazepine receptors make it a valuable tool for understanding the mechanisms behind these conditions.
Used in Neurological Research:
BETA-CCB is used as a research tool in the field of neuroscience to investigate the role of endogenous benzodiazepine binding inhibitors in the regulation of anxiety and seizure activity. This knowledge can contribute to the development of new therapeutic strategies for the treatment of neurological disorders.
Used in Drug Development:
BETA-CCB is used as a lead compound in the development of new drugs targeting benzodiazepine receptors. Its unique properties and effects on the central nervous system make it a promising candidate for the creation of novel therapeutic agents to treat anxiety and seizure disorders.
Biological Activity
An endogenous proconvulsant and anxiogenic benzodiazepine receptor ligand.
Check Digit Verification of cas no
The CAS Registry Mumber 84454-35-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,4,5 and 4 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 84454-35:
(7*8)+(6*4)+(5*4)+(4*5)+(3*4)+(2*3)+(1*5)=143
143 % 10 = 3
So 84454-35-3 is a valid CAS Registry Number.
InChI:InChI=1/C16H16N2O2/c1-2-3-8-20-16(19)14-9-12-11-6-4-5-7-13(11)18-15(12)10-17-14/h4-7,9-10,18H,2-3,8H2,1H3
84454-35-3Relevant academic research and scientific papers
HARMINE DERIVATIVES, INTERMEDIATES USED IN THEIR PREPARATION, PREPARATION PROCESSES AND USE THEREOF
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Page/Page column 18; 19; 95, (2008/06/13)
This invention relates to compounds of general formula (I), wherein R1, R2, R3, R4 and R5 are as defined specification; intermediates used in their preparation, preparation processes and use thereof. The present invention produce harmine derivatives with enhanced antihumour activity and lower nervous system toxicity by structurally modification parent structure of β-carboline of harmines at position 1, 2, 3, 7 and 9, The compounds of the present invention can be pre easily with high yield. They can be used in manufacture of a variety of antitumour medicines and medicines used in treatm tumour diseases in combination of light or radiation therapy.
β-Carbolines as benzodiazepine receptor ligands. 1. Synthesis and benzodiazepine receptor interaction of esters of β-carboline-3-carboxylic acid
Lippke,Schunack,Wenning,Muller
, p. 499 - 503 (2007/10/02)
Several esters of β-carboline-3-carboxylic acid were synthesized and tested in respect to their affinity for the benzodiazepine receptor in bovine cortex membranes. Out of these derivatives, the methyl, ethyl, and n-propyl ester were clearly the most pote
