84466-05-7

Usage

Uses

Amidoflumet is an Acaricide.

General Description

Miticide for house dust mites

InChI:InChI=1/C9H7ClF3NO4S/c1-18-8(15)6-4-5(10)2-3-7(6)14-19(16,17)9(11,12)13/h2-4,14H,1H3

Upstream product

• 5202-89-1 4-chlorobenzenesulfonyl chloride 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 421-83-0 trifluoromethane sulfonyl chloride 

Relevant academic research and scientific papers

Synthetic studies of fluorine-containing compounds for household insecticides

The discovery stories of three fluorine-containing insecticides in our laboratory are described, i.e. amidoflumet, a new trifluoromethanesulfonanilide with high miticidal activity against various house dust mites, Metofluthrin, a potent new fluorinated pyrethroid with extremely high knockdown activity against various mosquitoes, and a new α-pyrone compound, 3-[1R-trans-(2-trifluoromethyl)cyclopropanecarbonyl]-4-hydroxy-6-methyl-2-pyrone with outstanding insecticidal activity against Blattella germanica.

New trifluoromethanesulfonanilide compounds having high miticidal activity against house dust mites

Several 2-alkoxycarbonyltrifluoromethanesulfonanilides were prepared to examine their miticidal activity. 4-Halo-2- alkoxycarbonyltrifluoromethanesulfonanilides in particular showed good miticidal activity against Tyrophagus putrescentiae (Tp), Dermatophagoides farinae (Dp) and Chelacaropsis moorei (Cm). Amidoflumet (methyl 5-chloro-2-[(trifluoromethyl) sulfonyl]aminobenzoate) was selected and has been developed as a new miticide for house dust mites.

Process and reagent useful for the synthesis of sulphanilide which is perhalogenated on the carbon borne by the sulphur atom of the sulphanilide function

The present invention relates to a process and a reagent useful for the synthesis of sulphanilide which is perhalogenated on the carbon borne by the sulphur atom of the sulphanilide function. This persulphonylation process is characterized in that it comprises a step of placing a nucleophile, whose nucleophilic atom is a nitrogen, in contact with a reagent comprising, for successive or simultaneous addition, a heavy halide of sulphonyl, advantageously sulphonyl chloride, and an organic base comprising a trivalent atom from column V whose lone pair is conjugated directly or indirectly to a bond, and in that the organic part of the said sulphonyl is perhalogenated, advantageously perfluorinated, on the carbon borne by the sulphur. Application to the synthesis of intermediates for organic chemistry.