84467-19-6

Basic information

• Product Name: 1-(3,4-DICHLOROPHENYL)CYCLOBUTANECARBONITRILE
• Synonyms: 1-(3,4-DICHLOROPHENYL)CYCLOBUTANE-1-CARBONITRILE;1-(3,4-DICHLOROPHENYL)CYCLOBUTANECARBONITRILE;1-(3,4-dichlorophenyl)-1-cyclobutanecarbonitrile
• CAS NO: 84467-19-6
• Molecular Formula: C₁₁H₉Cl₂N
• Molecular Weight: 226.1
• Mol File: 84467-19-6.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(3,4-DICHLOROPHENYL)CYCLOBUTANECARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-DICHLOROPHENYL)CYCLOBUTANECARBONITRILE(84467-19-6)
• EPA Substance Registry System: 1-(3,4-DICHLOROPHENYL)CYCLOBUTANECARBONITRILE(84467-19-6)

Safety Data

• Hazardous Substances Data: 84467-19-6(Hazardous Substances Data)

Usage

Uses

1-(3,4-Dichlorophenyl)cyclobutanecarbonitrile is an intermediate in the synthesis of Chloro-sibutramine hydrochloride (C370150) which is a reagent used in the preparation of substituted cyclobutanes and their pharmaceutical compositions with antidepressant activity.

Upstream product

• 109-64-8 1,3-dibromo-propane 
• 3218-49-3 3,4-dichloro-benzeneacetonitrile 

Downstream Products

• 713482-88-3 [1-(3,4-dichlorophenyl)cyclobutyl]methylamine 
• 1358804-41-7 [1-(3,4-dichlorophenyl)cyclobutyl](pyridin-2-yl)methanone 
• 1358803-51-6 (±)-(1-(3,4-dichlorophenyl)cyclobutyl)(pyrimidin-2-yl)methanol 
• 1358803-52-7 (S)-[1-(3,4-dichlorophenyl)cyclobutyl](pyrimidin-2-yl)methanol 
• 1358803-53-8 (R)-[1-(3,4-dichlorophenyl)cyclobutyl](pyrimidin-2-yl)methanol 
• 1358803-39-0 (S)-[1-(3,4-dichlorophenyl)cyclobutyl](pyridin-2-yl)methanol 
• 84467-32-3 1-(3,4-dichlorophenyl)cyclobutane-1-carboxamide 
• 1432493-57-6 [1-(3,4-dichlorophenyl)cyclobutyl](5-methoxypyridin-2-yl)methanone 
• 1432051-64-3 [1-(3,4-dichlorophenyl)cyclobutyl](5-methoxypyridin-2-yl)methanol 

Relevant articles and documents

Oxadiazole Amine Derivative Compounds as Histone Deacetylase 6 Inhibitor, and the Pharmaceutical Composition Comprising the same

The present invention relates to a novel compound having an activity of inhibiting histone deacetylase 6 (HDAC6), an optical isomer thereof or a pharmaceutically acceptable salt thereof, a use thereof for preparation of a drug for treatment, a pharmaceutical composition comprising the same, a treatment method using the composition, and a method for preparing the same. The novel compound, an optical isomer thereof or a pharmaceutically acceptable salt thereof according to the present invention has an activity of inhibiting histone deacetylase 6 (HDAC6), and is effective for preventing or treating HDAC6-related diseases, including infectious diseases; neoplasm; endocrine, nutritional and metabolic diseases; mental and behavior disorders; nerve disorders; eye and adnexa diseases; cardiovascular diseases; respiratory diseases; digestive organ diseases; skin and subcutaneous tissue diseases; musculoskeletal and connective tissue diseases; or congenital malformation, deformation and chromosomal abnormality.COPYRIGHT KIPO 2017

Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor

The current work discloses a novel cyclohexylarylamine chemotype with potent inhibition of the serotonin, norepinephrine, and dopamine transporters and potential for treatment of major depressive disorder. Optimized compounds 1 (SERT, NET, DAT, IC50 = 169, 85, 21 nM) and 42 (SERT, NET, DAT IC50 = 34, 295, 90 nM) were highly brain penetrant, active in vivo in the mouse tail suspension test at 30 mpk po and were not general motor stimulants.

Process for the preparation of 1-aryl-1-cyanocyclobutane derivatives

A process for the preparation of arylcyclobutylnitrile derivatives which involves reaction of a solution of a 1,3-dihalopropane and a cyanobenzyl derivative in a substantialy dimethyl sulphoxide-free solvent with a suspension of a base in a substantially dimethyl sulphoxide-free solvent at a temperature of at least 35° C.