844681-90-9Relevant academic research and scientific papers
Inhibition of eEF2-K by thieno[2,3-b]pyridine analogues
Lockman, Jeffrey W.,Reeder, Matthew D.,Suzuki, Kazuyuki,Ostanin, Kirill,Hoff, Ryan,Bhoite, Leena,Austin, Harry,Baichwal, Vijay,Adam Willardsen
, p. 2283 - 2286 (2010)
Several series of thieno[2-3-b]pyridine analogues were synthesized and screened for inhibitory activity against eukaryotic elongation factor-2 kinase (eEF2-K). Modifications around several regions of the lead molecules were made, with a ring fusion adjacent to the nitrogen on the thienopyridine core being critical for activity. The most active compound 34 shows an IC50 of 170 nM against eEF2-K in vitro.
