844699-71-4Relevant academic research and scientific papers
Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode
Inagaki, Hiroaki,Tsuruoka, Hiroyuki,Hornsby, Michael,Lesley, Scott A.,Spraggon, Glen,Ellman, Jonathan A.
, p. 2693 - 2699 (2008/02/07)
The substrate activity screening (SAS) method, a substrate-based fragment identification and optimization method for the development of enzyme inhibitors, was previously applied to cathepsin S to obtain a novel (2-arylphenoxy) acetaldehyde inhibitor, 2, w
Combinatorial organic materials research (COMR): design, synthesis and screening of a 225-membered materials library of liquid crystalline fluorinated p-quaterphenyls
Deeg, Oliver,Baeurle, Peter
, p. 1609 - 1624 (2007/10/03)
The rapid solution phase synthesis of novel liquid crystalline materials is demonstrated by utilising combinatorial and parallel methods for the preparation of a library of 225 differently fluorinated 4,4?-dipropyl-p-quaterphenyl. Chemical diversity was i
