84477-72-5

Usage

Uses

Used in Pharmaceutical Synthesis:
2,2-DIMETHYL-PIPERAZINE is utilized as a building block in the synthesis of pharmaceuticals, contributing to the development of various medicinal compounds due to its structural and reactive properties.
Used in Agrochemical Production:
In the agrochemical industry, 2,2-DIMETHYL-PIPERAZINE serves as a key component in the creation of compounds designed to protect crops and enhance agricultural productivity.
Used as a Curing Agent in Epoxy Resins:
2,2-DIMETHYL-PIPERAZINE is employed as a curing agent for epoxy resins, enhancing their properties and performance in various applications, including coatings, adhesives, and composite materials.
Used as a Corrosion Inhibitor in Metalworking Fluids:
2,2-DIMETHYL-PIPERAZINE is used as a corrosion inhibitor in metalworking fluids, helping to prevent the degradation of metal surfaces during manufacturing processes and extending the life of machinery and tools.
Used in Drug Delivery Systems:
2,2-DIMETHYL-PIPERAZINE has been evaluated for its potential as a drug delivery agent, particularly for targeting cancer cells and overcoming multidrug resistance, showcasing its utility in improving therapeutic outcomes in oncology.

InChI:InChI=1/C6H14N2/c1-6(2)5-7-3-4-8-6/h7-8H,3-5H2,1-2H3

Upstream product

• 153627-83-9 2,2-dimethyl-1,2,5,6-tetrahydropyrazine 
• 22476-74-0 3,3-dimethyl-piperazin-2-one 

Downstream Products

• 936706-64-8 C₂₃H₃₁N₅O₃ 
• 1035271-22-7 ethyl 4-(3,3-dimethylpiperazin-1-yl)benzoate 

Relevant academic research and scientific papers

PROCESS FOR THE PREPARATION OF 2,2-DIMETHYLPIPERAZINE

This invention relates to a novel chemical process for the synthesis of 2,2-dimethylpiperazine and the further transformation of 2,2-dimethylpiperazine into ferf-butyl-3,3-dimethylpiperazine-l- carboxylate-hemi-DL-tartrate.

COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS

The present application provides novel optionally substituted fused pyridine and pyrimidine bicyclic compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in co-regulating FAK and/or Src activity by administering a therapeutically effective amount of one or more of the compounds to a subject. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the FAK and/or Src pathway. Advantageously, these compounds perform as dual FAK and/or Src inhibitors. A variety of conditions can be treated using these compounds and include diseases which are characterized by inflammation or abnormal cellular proliferation. In one embodiment, the disease is cancer.

COMPOUNDS, THEIR PHARMACEUTICAL COMPOSITIONS AND THEIR USES AS IDH1 MUTANTS INHIBITORS FOR TREATING CANCERS

Provided are compounds of formula (I), wherein X, Y, Z, W, V, R2, R3 and m are defined as in the description. Their pharmaceutical compositions and their uses as IDH1 mutants inhibitors for treating cancers are also provided

Pharmaceutical compounds

Compounds of Formulae Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia and Ib for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

ALPHA-UNSUBSTITUTED ARYLMETHYL PIPERAZINE PYRAZOLO[1,5-A] PYRIMIDINE AMIDE DERIVATIVES

Methods of preventing, treating or delaying the onset of HIV in a subject by administering to the subject novel pharmaceutically active arylmethyl pyrazolo[1,5-α ]pyrimidine amide derivatives, or pharmaceutical compositions containing the same are described. Additionally, compounds of novel pharmaceutically active arylmethyl piperazine pyrazolo[l,5-α]pyrimidine amide derivatives and their use for the manufacture of specific medicaments are described.

CRYSTALLINE BASE OF TRANS-1-((1R,3S)-6-CHLORO-3-PHENYLINDAN-1-YL)-3,3-DIMETHYLPIPERAZINE

Crystalline base of compound trans-1-((1R,3S)-6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine, processes for the preparation of purified free base or salts of this compound, pharmaceutical compositions comprising the base and medical use thereof, incl

TARTRATE AND MALATE SALTS OF TRANS-1-((1R,3S)-6-CHLORO-3-PHENYLINDAN-1-YL)-3,3-DIMETHYLPIPERAZINE

A tartrate and malate salt of trans-1-(6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine, in particular for medical use, pharmaceutical formulations thereof, including for treatment of schizophrenia or other diseases involving psychotic symptoms.

PROCESS FOR MAKING TRANS-1-((1R, 3S)-6-CHLORO-3-PHENYLINDAN-1-YL)-3, 3-DIMETHYLPIPERAZINE

Described is a method for making the trans-1-((1R,3S)-6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine (formula I) and salts thereof and a similar method for making 4-((1R,3S)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine (formula IX) and salt

SUCCINATE AND MALONATE SALT OF TRANS-4-(IR,3S)-6-CHLORO-3-PHENYLINDAN-1-YL)-1,2,2-TRIMETHYLPIPERAZINE AND THE USE AS A MEDICAMENT

4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine hydrogen succinate or hadrogen malonat, pharmaceutical compositions containing these salts and the medical use thereof, including for the treatment of schizophrenia and other psychotic diso

1-PIPERAZINO-1,2-DIHYDROINDENE DERIVATIVES

Trans isomers of 1-piperazino-1,2-dihydroindene compounds having formula (I), I wherein X and Y are hydrogen, halogen, trifluoromethyl, alkyl, alkylthio, trifluoromethylthio, alkoxy, hydroxy, alkylsulfonyl, amino, alkylamino, nitro or cyano; Ar is