84477-72-5

Basic information

• Product Name: 2,2-DIMETHYL-PIPERAZINE
• Synonyms: 2,2-DiMethyl-piperazine 2HCl;2,2-DIMETHYL-PIPERAZINE;Piperazine, 2,2-dimethyl-
• CAS NO: 84477-72-5
• Molecular Formula: C₆H₁₄N₂
• Molecular Weight: 114.19
• Product Categories: pharmacetical
• Mol File: 84477-72-5.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 155.174 °C at 760 mmHg
• Flash Point: 38.899 °C
• Appearance: /
• Density: 0.834 g/cm³
• Vapor Pressure: 3.069mmHg at 25°C
• Refractive Index: 1.417
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 9.38±0.40(Predicted)
• CAS DataBase Reference: 2,2-DIMETHYL-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIMETHYL-PIPERAZINE(84477-72-5)
• EPA Substance Registry System: 2,2-DIMETHYL-PIPERAZINE(84477-72-5)

Safety Data

• Hazard Codes: Xi,N
• Statements: 42-51/53
• Safety Statements: 61
• RIDADR: UN3077
• Hazardous Substances Data: 84477-72-5(Hazardous Substances Data)

Usage

General Description

2,2-DIMETHYL-PIPERAZINE is a chemical compound with the molecular formula C6H14N2. It is a cyclic amine consisting of two nitrogen atoms and two methyl groups attached to a six-membered ring. 2,2-DIMETHYL-PIPERAZINE is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used as a curing agent for epoxy resins and as a corrosion inhibitor in metalworking fluids. In addition, 2,2-DIMETHYL-PIPERAZINE has been evaluated for its potential as a drug delivery agent, particularly for targeting cancer cells and overcoming multidrug resistance. It is considered to be a valuable intermediate in organic synthesis due to its versatile reactivity and its ability to easily undergo substitution reactions.

InChI:InChI=1/C6H14N2/c1-6(2)5-7-3-4-8-6/h7-8H,3-5H2,1-2H3

Upstream product

• 22476-74-0 3,3-dimethyl-piperazin-2-one 
• 153627-83-9 2,2-dimethyl-1,2,5,6-tetrahydropyrazine 

Downstream Products

• 223786-42-3 2,2-dimethyl-4-(4-nitro-phenyl)-piperazine 
• 846052-64-0 trans-1-((1R,3S)-6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine 
• 906816-56-6 trans-1-((1R,3S)-6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazinium hydrogen chloride 
• 1039734-66-1 N-[4-({[2-(3,3-dimethylpiperazin-1-yl)-7-methylquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide 
• 1431542-32-3 [3-(6-bromo-quinazolin-4-yl)-phenyl]-(3,3-dimethyl-piperazin-1-yl)-methanone 
• 1095534-31-8 (1R,2R)-N-(1-cyanocyclopropyl)-2-({2,2-dimethyl-4-[4-(methylsulfonyl)phenyl]piperazin-1-yl}carbonyl)cyclohexanecarboxamide 
• 1095538-51-4 3,3-dimethyl-1-[4-(methylsulfonyl)phenyl]piperazine 
• 1201673-46-2 6-(3,3-dimethylpiperazin-1-yl)-2'-cyclohexylamino-[2,4']bipyridinyl-4-carboxylic acid methyl ester 
• 1035269-93-2 N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-5-(3,3-dimethylpiperazin-1-yl)pyrazine-2-carboxamide 
• 1035270-24-6 N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,3-dimethylpiperazin-1-yl)benzamide 
• 1035271-22-7 ethyl 4-(3,3-dimethylpiperazin-1-yl)benzoate 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF 2,2-DIMETHYLPIPERAZINE

This invention relates to a novel chemical process for the synthesis of 2,2-dimethylpiperazine and the further transformation of 2,2-dimethylpiperazine into ferf-butyl-3,3-dimethylpiperazine-l- carboxylate-hemi-DL-tartrate.

COMPOUNDS, THEIR PHARMACEUTICAL COMPOSITIONS AND THEIR USES AS IDH1 MUTANTS INHIBITORS FOR TREATING CANCERS

Provided are compounds of formula (I), wherein X, Y, Z, W, V, R2, R3 and m are defined as in the description. Their pharmaceutical compositions and their uses as IDH1 mutants inhibitors for treating cancers are also provided

ALPHA-UNSUBSTITUTED ARYLMETHYL PIPERAZINE PYRAZOLO[1,5-A] PYRIMIDINE AMIDE DERIVATIVES

Methods of preventing, treating or delaying the onset of HIV in a subject by administering to the subject novel pharmaceutically active arylmethyl pyrazolo[1,5-α ]pyrimidine amide derivatives, or pharmaceutical compositions containing the same are described. Additionally, compounds of novel pharmaceutically active arylmethyl piperazine pyrazolo[l,5-α]pyrimidine amide derivatives and their use for the manufacture of specific medicaments are described.