84478-72-8

Usage

Uses

Used in Pharmaceutical Industry:
5-amino-2-chloro-4-fluoro-phenol is used as an intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into the molecular structures of various drugs. Its unique functional groups allow for the development of new therapeutic agents with specific biological activities.
Used in Agrochemical Industry:
In the agrochemical sector, 5-amino-2-chloro-4-fluoro-phenol serves as a key intermediate in the production of agrochemicals, such as pesticides and herbicides. Its chemical properties enable the creation of effective compounds designed to protect crops and enhance agricultural productivity.
Used in Specialty Chemicals Manufacturing:
5-amino-2-chloro-4-fluoro-phenol is utilized in the manufacturing of specialty chemicals, where its distinct chemical structure contributes to the development of high-performance materials for specific applications, such as in coatings, adhesives, and polymers.
Used in Organic Chemistry Research:
As a building block in organic chemistry, 5-amino-2-chloro-4-fluoro-phenol is employed in research for the synthesis of complex organic molecules and the exploration of novel chemical reactions. Its presence in these reactions can lead to the discovery of new compounds with potential applications in various industries.
Used in Dye Production:
5-amino-2-chloro-4-fluoro-phenol has potential use as an intermediate in the production of various dyes due to its ability to be modified and incorporated into dye molecules. This allows for the creation of dyes with specific color properties and improved performance characteristics for use in textiles, inks, and other applications.

InChI:InChI=1/C6H5ClFNO/c7-3-1-4(8)5(9)2-6(3)10/h1-2,10H,9H2

Upstream product

• 371-41-5 4-Fluorophenol 
• 1996-41-4 2-chloro-4-fluorophenol 
• 84478-88-6 2-chloro-4-fluoro-methoxycarbonyloxybenzene 
• 84478-75-1 2-chloro-4-fluoro-5-nitrophenol 
• 84478-89-7 2-chloro-4-fluoro-5-nitro-methoxycarbonyloxybenzene 

Downstream Products

• 84478-41-1 2-(4-Chloro-2-fluoro-5-hydroxyphenyl)-4,5,6,7-tetrahydro-2H-isoindole-1,3-dione 
• 122855-03-2 3-[(E)-4-Chloro-2-fluoro-5-hydroxy-phenylimino]-4,5,6,7-tetrahydro-3H-isobenzofuran-1-one 
• 174813-45-7 2-(4-Chloro-2-fluoro-5-hydroxy-phenyl)-5,6-dimethyl-3-methylene-2,3-dihydro-isoindol-1-one 
• 174813-42-4 2-(4-Chloro-2-fluoro-5-hydroxy-phenyl)-5-fluoro-3-methylene-2,3-dihydro-isoindol-1-one 
• 174813-43-5 5-Chloro-2-(4-chloro-2-fluoro-5-hydroxy-phenyl)-3-methylene-2,3-dihydro-isoindol-1-one 
• 174813-46-8 5,7-Dichloro-2-(4-chloro-2-fluoro-5-hydroxy-phenyl)-3-methylene-2,3-dihydro-isoindol-1-one 
• 205447-28-5 4-(4-chloro-2-fluoro-5-hydroxyanilino)-6,7-dimethoxyquinoline hydrochloride 
• 205447-99-0 6,7-dimethoxy-3-fluoro-4-(4-chloro-2-fluoro-5-hydroxyanilino)quinoline 
• 205447-37-6 4-(4-chloro-2-fluoro-5-hydroxyanilino)-6-methoxy-7-(2-methylthiazol-4-ylmethoxy)quinoline hydrochloride 
• 742681-01-2 4-(4-chloro-2-fluoro-5-hydroxyanilino)-6-methoxy-7-(3-(3-pyridyl)propoxy)quinoline 
• 205448-05-1 4-(4-chloro-2-fluoro-5-hydroxyanilino)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinoline 
• 224168-10-9 N-(4-chloro-2-fluoro-5-hydroxyphenyl)phthalimide 
• 213675-94-6 4-Chloro-2-fluoro-5-(2-pyrimidinyloxy)-benzenamine 
• 141772-32-9 2-fluoro-4-chloro-5-cyclopentyloxyaniline 

Relevant academic research and scientific papers

Development of a scalable synthesis of a vascular endothelial growth factor receptor-2 kinase inhibitor: Efficient construction of a 6-etherified [1,2,4]triazolo[1,5-a]pyridine-2-amine Core

A practical and scalable synthesis of the vascular endothelial growth factor receptor-2 (VEGFR-2) kinase inhibitor 1 has been developed. The key features of the process development include facile preparation of the key raw material 3-amino-4- fluorophenol, chemoselective nucleophilic aromatic substitution of 5-chloro-2-nitropyridine with phenol, a safe one-pot synthesis of a substituted urea using an isothiocyanate generated in situ from inexpensive materials, and improvement of the yield of acylation in the end game. The optimized six-step synthesis afforded 1·H2O in 54% overall yield, twice as much as the yield of the original synthesis, without chromatographic purification. In addition, a robust recrystallization procedure to afford the desired crystal form of 1 was also developed.

Compounds and Methods of Treatment

A derivative, which is useful as a ret kinase inhibitor is described herein. The described invention also includes methods of using the same in the treatment of diseases mediated by inappropriate ret kinase activity.

Quinoline derivatives inhibiting the effect of growth factors such as VEGF

Compounds of the formula (I): wherein: R2represents hydroxy, halogeno, C1-3alkyl, C1-3alkoxy, C1-3alkanoyloxy, trifluoromethyl, cyano, amino or nitro; n is an integer from 0 to 5; Z represents —O—, —NH—, —S— or —CH2—; G1represents phenyl or a 5-10 membered heteroaromatic cyclic or bicyclic group; Y1, Y2, Y3and Y4each independently represents carbon or nitrogen; R1represents fluoro or hydrogen; m is an integer from 1 to 3; R3represents hydrogen, hydroxy, halogeno, cyano, nitro, trifluoromethyl, C1-3alkyl, —NR4R5(wherein R4and R5, can each be hydrogen or C1-3alkyl), or a group R6—X1— wherein X1represents —CH2— or a heteroatom linker group and R6is an alkyl, alkenyl or alkynyl chain optionally substituted by for example hydroxy, amino, nitro, alkyl, cycloalkyl, alkoxyalkyl, or an optionally substituted group selected from pyridone, phenyl and a heterocyclic ring, which alkyl, alkenyl or alkynyl chain may have a heteroatom linker group, or R6is an optionally substituted group selected from pyridone, phenyl and a heterocyclic ring and salts thereof, in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals such as humans, processes for the preparation of such derivatives, pharmaceutical compositions containing a compound of formula I or a pharmaceutically acceptable salt thereof as active ingredient and compounds of formula I. The compounds of formula I and the pharmaceutically acceptable salts thereof inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis.

Production of pyridazine herbicides

PCT No. PCT/JP97/03726 Sec. 371 Date Apr. 9, 1999 Sec. 102(e) Date Apr. 9, 1999 PCT Filed Oct. 16, 1997 PCT Pub. No. WO98/17632 PCT Pub. Date Apr. 30, 1998Carboxylic acids of formula (1): wherein R2 and R3 are independently hydrogen or C1-C3 alkyl, and Q

A facile synthetic method of herbicidal 2,-dihydro-3-methylene-2-substituted - phenyl-1hisoindol-1-one derivatives

Herbicidal 2,3-dihydro-3-methylene-2-substitutedphenyl-1 H-isoindol-1-one derivatives 7 have been synthesized. They were prepared from the easily available phenol derivatives 1 in 5 steps in moderate yields.

Tetrahydrophthalimide compounds, as post-emergence herbicides for use in soybean fields

A tetrahydrophthalimide compound of the formula: STR1 wherein R is methyl or n-pentyl, which is useful as a post emergent herbicide for a soybean field.

Tetrahydrophthalimides, and their production and use

A compound of the formula: STR1 wherein X is a chlorine atom or a bromine atom, which is useful as a herbicide.