844817-69-2 Usage
Description
(1S)CYCLOPROPYL(2-FLUOROPHENYL)METHYLAMINE is a chemical compound with the molecular formula C11H14FN. It is a cyclopropyl-substituted phenyl methylamine, with a fluorine atom attached to the second position of the phenyl ring. This unique structure and chemical properties make it a valuable tool for the development of new pharmaceutical compounds.
Uses
Used in Pharmaceutical Industry:
(1S)CYCLOPROPYL(2-FLUOROPHENYL)METHYLAMINE is used as a building block for the synthesis of various drugs, including potential therapeutic agents. Its potential applications in medicinal chemistry and drug discovery research make it a promising candidate for the development of new pharmaceutical compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 844817-69-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,4,8,1 and 7 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 844817-69:
(8*8)+(7*4)+(6*4)+(5*8)+(4*1)+(3*7)+(2*6)+(1*9)=202
202 % 10 = 2
So 844817-69-2 is a valid CAS Registry Number.
844817-69-2Relevant articles and documents
New quinoline NK3 receptor antagonists with CNS activity
Smith, Paul W.,Wyman, Paul A.,Lovell, Peter,Goodacre, Caroline,Serafinowska, Halina T.,Vong, Antonio,Harrington, Frank,Flynn, Sean,Bradley, Daniel M.,Porter, Rod,Coggon, Sara,Murkitt, Graham,Searle, Kirsten,Thomas, David R.,Watson, Jeannette M.,Martin, William,Wu, Zining,Dawson, Lee A.
scheme or table, p. 837 - 840 (2009/09/06)
Lead optimisation starting from the previously reported selective quinoline NK3 receptor antagonists talnetant 2 (SB-223412) and 3 (SB-222200) led to the identification of 3-aminoquinoline NK3 antagonist 10 (GSK172981) with excellent CNS penetration. Investigation of a structurally related series of sulfonamides with reduced lipophilicity led to the discovery of 20 (GSK256471). Both 10 and 20 are high affinity, potent NK3 receptor antagonists which despite having different degrees of CNS penetration produced excellent NK3 receptor occupancy in an ex vivo binding study in gerbil cortex.
