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Usage

Uses

Used in Organic Synthesis:
2-BROMO-6-IODOANILINE is used as a key intermediate in organic synthesis for the production of a variety of compounds. Its unique structure allows it to participate in numerous chemical reactions, making it a valuable building block in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-BROMO-6-IODOANILINE is utilized as a precursor in the synthesis of various drugs. Its presence in the molecular structure can influence the pharmacological properties of the final product, contributing to the development of new therapeutic agents.
Used in Agrochemicals:
2-BROMO-6-IODOANILINE is also used in the agrochemical sector as a starting material for the synthesis of pesticides and other crop protection agents. Its chemical properties enable the creation of compounds that can effectively control pests and diseases in agriculture.
Used in Dyes and Pigments Industry:
Due to its ability to undergo various chemical reactions, 2-BROMO-6-IODOANILINE is used in the synthesis of dyes and pigments. It contributes to the development of colorants with specific properties, such as color intensity and stability, for use in various applications including textiles, plastics, and inks.
Used in Medicinal Chemistry Research:
2-BROMO-6-IODOANILINE has been studied for its potential biological activities, including antimicrobial and antitumor properties. It is used as a subject of interest in medicinal chemistry research to explore its therapeutic potential and to develop new drugs based on its chemical structure.

Upstream product

• 615-36-1 2-bromoaniline 
• 1022128-96-6 2-bromo-6-iodobenzoic acid 
• 615-43-0 2-iodophenylamine 

Downstream Products

• 1126425-84-0 1-bromo-3-iodo-2-nitrobenzene 
• 16807-11-7 1-bromo-9H-carbazole 
• 1420010-31-6 C₂₈H₃₃BrN₂O₅ 

Relevant academic research and scientific papers

A dramatic enhancing effect of InBr3 towards the oxidative Sonogashira cross-coupling reaction of 2-ethynylanilines

The addition of InBr3 to the oxidative Sonogashira cross-coupling reaction of 2-ethynylaniline with (E)-trimethyl(3,3,3-trifluoroprop-1-enyl)silane led to a dramatic increase in the reactivity to afford the corresponding 1,3-enynes bearing a trifluoromethyl group on their terminal sp2 carbon. The subsequent cyclization of these 1,3-enynes under palladium catalysis provides access to the corresponding indoles bearing a 3,3,3-trifluoroprop-1-enyl group at their 2-position.

Remarkable switch in the regiochemistry of the iodination of anilines by N-iodosuccinimide: Synthesis of 1,2-dichloro-3,4-diiodobenzene

Direct iodination of anilines by NIS in polar solvents (such as DMSO) affords p-iodinated products with up to >99% regioselectivity. Switching to less polar solvents (such as benzene) in the presence of AcOH inverts this outcome toward dramatically increased or preferential generation of the o-isomers, also with up to >99% regioselectivity. This finding was exploited in the synthesis of 1,2-dichloro-3,4-diiodobenzene. Georg Thieme Verlag Stuttgart - New York.

Synthesis of pyrrolnitrin and related halogenated phenylpyrroles

A general approach to halogenated arylpyrroles, including the antifungal natural product pyrrolnitrin, is described using newly synthesized halogenated pyrroles and 2,6-disubstituted nitrobenzenes or 2,6-disubstituted anilines.

Mild and regioselective oxidative bromination of anilines using potassium bromide and sodium perborate

The selective monobromination of various deactivated anilines using potassium bromide and sodium perborate as oxidant has been achieved. The use of ammonium molybdate as catalyst accelerates the rate of reaction but is not essential to obtain good yields and high selectivities. (C) 2000 Elsevier Science Ltd.