844875-53-2

Basic information

• Product Name: C₂₉H₃₅N₅O₄
• CAS NO: 844875-53-2
• Molecular Weight: 517.628
• Mol File: 844875-53-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₉H₃₅N₅O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₉H₃₅N₅O₄(844875-53-2)
• EPA Substance Registry System: C₂₉H₃₅N₅O₄(844875-53-2)

Safety Data

• Hazardous Substances Data: 844875-53-2(Hazardous Substances Data)

Upstream product

• 67015-06-9 N'-hydroxypentanimidamide 
• 844876-40-0 C₂₄H₂₆ClN₃O₄ 

Relevant articles and documents

Discovery of pyrrolopyridazines as novel DGAT1 inhibitors

A new structural class of DGAT1 inhibitors was discovered and the structure-activity relationship was explored. The pyrrolotriazine core of the original lead molecule was changed to a pyrrolopyridazine core providing an increase in potency. Further exploration resulted in optimization of the propyl group at C7 and the discovery that the ester at C6 could be replaced by five-membered heterocyclic rings. The analogs prepared have DGAT1 IC 50 values ranging from >10 μM to 48 nM.