844882-19-5

Basic information

• Product Name: 3,3-dimethyl-1-pyrrolidin-1-ylbutan-2-amine
• Synonyms: 1-pyrrolidineethanamine, alpha-(1,1-dimethylethyl)-
• CAS NO: 844882-19-5
• Molecular Formula: C₁₀H₂₂N₂
• Molecular Weight: 170.2951
• Mol File: 844882-19-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 219.8°C at 760 mmHg
• Flash Point: 85.2°C
• Density: 0.908g/cm³
• Vapor Pressure: 0.117mmHg at 25°C
• Refractive Index: 1.48
• CAS DataBase Reference: 3,3-dimethyl-1-pyrrolidin-1-ylbutan-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3-dimethyl-1-pyrrolidin-1-ylbutan-2-amine(844882-19-5)
• EPA Substance Registry System: 3,3-dimethyl-1-pyrrolidin-1-ylbutan-2-amine(844882-19-5)

Safety Data

• Hazardous Substances Data: 844882-19-5(Hazardous Substances Data)

Upstream product

• 171092-50-5 (S)-2-Amino-3,3-dimethyl-1-pyrrolidin-1-yl-butan-1-one 
• 1380104-03-9 (S)-tert-butyl 3,3-dimethyl-1-oxo-1-(pyrrolidin-1-yl)butan-2-ylcarbamate 
• 62965-35-9 N-tert-butyloxycarbonyl-L-tert-leucine 
• 20859-02-3 L-tert-Leucine 

Relevant articles and documents

Asymmetric Synthesis of Carbocyclic Propellanes

A modular synthesis of functionalized carbocyclic propellanes was developed. Formation of the first of two quaternary bridgehead centers has been achieved by desymmetrization of prostereogenic ketones by either Hajos-Parrish-Eder-Sauer-Wiechert-type processes or Werner’s catalytic asymmetric Wittig reaction. The obtained bicyclic enones were subjected to conjugate additions upon which the remaining ring was formed by olefin metathesis. All bridges are amenable to further derivatization, which renders those compounds useful as central units in fragment-based drug discovery or as ligand scaffolds.