84490-12-0

Usage

Uses

Cardiotonic.

InChI:InChI=1/C11H11N3O2/c1-2-8-9(14-11(16)13-8)10(15)7-3-5-12-6-4-7/h3-6H,2H2,1H3,(H2,13,14,16)

Upstream product

• 14254-57-0 4-(chlorocarbonyl)pyridine 
• 83962-06-5 1,2-dihydro-4-ethyl-2H-imidazol-2-one 
• 25108-37-6 potassium pyridine-4-carboxylate 

Downstream Products

• 55-22-1 pyridine-4-carboxylic acid 

Relevant academic research and scientific papers

Preparation of 1,3-dihydro-4-pyridoyl-2H-imidazol-2-ones

1,3-Dihydro-4-pyridoyl-2H-imidazol-2-ones are prepared in a three step process by (a) reducing 1-pyridyl-1,3-deketo-2-oximinoalkanes to produce 1-pyridyl-1-hydroxy-2-amine-3-ketoalkanes; (b) reacting the thus produced hydroxyaminoketone with cyanate ion to produce a 1,3-dihydro-4-hydroxy(pyridyl)methyl-2H-imidazol-2-one; and (c) oxidizing the thus produced hydroxymethyl compound to yield the desired product.

4-Aroyl-1,3-dihydro-2H-imidazol-2-ones: A New Class of Cardiotonic Agents. 2. Effect of 4-Pyridoyl Substituents and Related Compounds

A group of 4-pyridoyl-1,3-dihydro-2H-imidazol-2-ones was prepared and tested for inotropic activity in the anesthetized dog.Positive inotropic effects as well as increases in heart rate and decreases in blood pressure were noted for most of these compounds.One of the compounds (8) is currently undergoing clinical trials for the treatment of congestive heart failure.