844902-57-4Relevant academic research and scientific papers
Discovery of 1-(3-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl) -2-imidazolidinone (GSK163090), a potent, selective, and orally active 5-HT 1A/B/D receptor antagonist
Leslie, Colin P.,Biagetti, Matteo,Bison, Silvia,Bromidge, Steven M.,Di Fabio, Romano,Donati, Daniele,Falchi, Alessandro,Garnier, Martine J.,Jaxa-Chamiec, Albert,Manchee, Gary,Merlo, Giancarlo,Pizzi, Domenica A.,Stasi, Luigi P.,Tibasco, Jessica,Vong, Antonio,Ward, Simon E.,Zonzini, Laura
experimental part, p. 8228 - 8240 (2011/02/21)
In an effort to identify selective drug like pan-antagonists of the 5-HT1 autoreceptors, studies were conducted to elaborate a previously reported dual acting 5-HT1 antagonist/SSRI structure. A novel series of compounds was identifie
QUINOLINE AND QUINAZOLINE DERIVATIVES HAVING AFFINITY FOR 5HT1-TYPE RECEPTORS
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Page/Page column 31, (2008/06/13)
Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided: wherein R1, m, X, R2, n, W, p, Y, Z, R3, R4, R5 and q have the meanings as defined in the description. Methods of preparation and uses thereof in therapy, particularly for CNS disorders such as depression or anxiety, are also disclosed.
