844903-12-4Relevant academic research and scientific papers
Discovery of 1-(3-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl) -2-imidazolidinone (GSK163090), a potent, selective, and orally active 5-HT 1A/B/D receptor antagonist
Leslie, Colin P.,Biagetti, Matteo,Bison, Silvia,Bromidge, Steven M.,Di Fabio, Romano,Donati, Daniele,Falchi, Alessandro,Garnier, Martine J.,Jaxa-Chamiec, Albert,Manchee, Gary,Merlo, Giancarlo,Pizzi, Domenica A.,Stasi, Luigi P.,Tibasco, Jessica,Vong, Antonio,Ward, Simon E.,Zonzini, Laura
experimental part, p. 8228 - 8240 (2011/02/21)
In an effort to identify selective drug like pan-antagonists of the 5-HT1 autoreceptors, studies were conducted to elaborate a previously reported dual acting 5-HT1 antagonist/SSRI structure. A novel series of compounds was identifie
