84494-70-2

Basic information

• Product Name: EICOSAPENTAENOIC ACID ETHYL ESTER
• Synonyms: EICOSAPENTAENOIC ACID ETHYL ESTER;EPA EE;ETHYL 5,8,11,14,17-EICOSAPENTAENOATE;ICOSAPENTAENOIC ACID ETHYL ESTER;5,8,11,14,17-eicosapentaenoicacid,ethylester;5,8,11,14,17-eicosapentaenoicacidethylester;5,8,11,14,17-Icosapentaenoic acid ethyl ester
• CAS NO: 84494-70-2
• Molecular Formula: C22H34O2
• Molecular Weight: 330.5
• Product Categories: Fatty Acids Ethyl Ester - Unlabeled
• Mol File: 84494-70-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 417 °C at 760 mmHg
• Flash Point: 103.1 °C
• Appearance: /
• Density: 0.909 g/cm³
• Vapor Pressure: 3.65E-07mmHg at 25°C
• Refractive Index: 1.495
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Sparingly), Methanol (Slightly)
• CAS DataBase Reference: EICOSAPENTAENOIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: EICOSAPENTAENOIC ACID ETHYL ESTER(84494-70-2)
• EPA Substance Registry System: EICOSAPENTAENOIC ACID ETHYL ESTER(84494-70-2)

Safety Data

• Hazardous Substances Data: 84494-70-2(Hazardous Substances Data)

Usage

Description

Ethyl icosapentate is an ester of a polyunsaturated acid derived from fish oil. It is reported to decrease platelet aggregation, reduce blood viscosity and increase erythrocyte deformability.

Originator

Nippon Suisan (Japan)

Brand name

Epadel

InChI:InChI=1/C22H34O2/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24-4-2/h5-6,8-9,11-12,14-15,17-18H,3-4,7,10,13,16,19-21H2,1-2H3/b6-5+,9-8+,12-11+,15-14+,18-17+

Upstream product

• 64-17-5 ethanol 
• 1553-41-9 5,8,11,14,17-eicosapentaenoic acid 
• 10417-94-4 all cis-5,8,11,14,17-eicosapentaenoic acid 
• 122-51-0 orthoformic acid triethyl ester 
• 105-58-8 Diethyl carbonate 

Downstream Products

• 234087-68-4 all-(Z)-ethyl 3-oxa-6,9,12,15-octadecatetraenoate 

Relevant articles and documents

Preparation of n-3 PUFAs ethyl esters by an efficient biocatalyzed solvent-free process

alpha-Linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been subjected to esterification with ethanol in presence of lipase B from Candida antarctica (Novozym 435), in solvent free condition. The use of alcohol donors triethyl orthoformate (TEOF) or diethyl carbonate (DEC) instead of free ethanol, allowed working in irreversible esterification conditions and ALA-, EPA- and DHA-ethyl esters were obtained in quantitative yields.

Process for the preparation of a composition comprising unsaturated compounds

The present invention relates to a process for the preparation of a composition comprising unsaturated compounds, in particular polyunsaturated compounds, which comprises concentrating and purifying the compounds by contact with silicon and/or aluminium derivatives. The process of the invention represents an advantageous substitute of the usual distillation processes, coupled or not to chromatographic processes, and allows to isolate and remove polar byproducts.

Characteristics of Lipase Modified with Water-soluble Acylating Reagents and Its Esterification Ability

Lip was modified with various hydrophobic groups, such as Z, Boc, lauroyl, and palmitoyl, using water-soluble acylating reagents.The chemical modification enhanced the dispersibility of Lip in organic solvents, and changed the substrate selectivity, which depends on the length of the carbon chain of triglycerides in hydrolytic reactions.As for the synthesis of triglycerides, Z-modified Lip catalyzed this reaction faster than unmodified Lip.Z-, Boc-, and fatty acid-modified Lips also catalyzed diverse esterification reactions including that of ethyl eicosapentaenoate, lactose oleate, and cholesterol oleate, and the yields of these reactions increased depending on the carbon number of the introducing group.