84494-70-2

Usage

Uses

Used in Pharmaceutical Industry:
EICOSAPENTAENOIC ACID ETHYL ESTER is used as a therapeutic agent for the treatment of cardiovascular diseases. It helps in reducing the risk of heart attacks, strokes, and other related conditions by improving blood flow and preventing clot formation.
Used in Nutritional Supplements:
EICOSAPENTAENOIC ACID ETHYL ESTER is used as a dietary supplement to support heart health and overall well-being. It provides essential omega-3 fatty acids that are crucial for maintaining a healthy cardiovascular system.
Used in Research and Development:
EICOSAPENTAENOIC ACID ETHYL ESTER is used as a key component in scientific studies and research aimed at understanding the role of omega-3 fatty acids in human health and disease prevention. It helps researchers explore the potential benefits and mechanisms of action of these essential nutrients.

Originator

Nippon Suisan (Japan)

InChI:InChI=1/C22H34O2/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24-4-2/h5-6,8-9,11-12,14-15,17-18H,3-4,7,10,13,16,19-21H2,1-2H3/b6-5+,9-8+,12-11+,15-14+,18-17+

Upstream product

• 10417-94-4 all cis-5,8,11,14,17-eicosapentaenoic acid 
• 64-17-5 ethanol 
• 105-58-8 Diethyl carbonate 
• 122-51-0 orthoformic acid triethyl ester 
• 1553-41-9 5,8,11,14,17-eicosapentaenoic acid 

Downstream Products

• 234087-68-4 all-(Z)-ethyl 3-oxa-6,9,12,15-octadecatetraenoate 

Relevant academic research and scientific papers

Preparation of n-3 PUFAs ethyl esters by an efficient biocatalyzed solvent-free process

alpha-Linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been subjected to esterification with ethanol in presence of lipase B from Candida antarctica (Novozym 435), in solvent free condition. The use of alcohol donors triethyl orthoformate (TEOF) or diethyl carbonate (DEC) instead of free ethanol, allowed working in irreversible esterification conditions and ALA-, EPA- and DHA-ethyl esters were obtained in quantitative yields.

Compositions and methods of omega polyunsaturated fatty acids for the treatment of oral diseases

The invention discloses a novel discovery of anti-microbial activity against oral bacteria, which can be applied for controlling and preventing oral diseases, of omega-3, omega-6, and omega-9 fatty acids, but not limited to omega-3, omega-6, and omega-9 fatty acids; omega-3, omega-6, and omega-9 fatty acid methyl esters, and omega-3, omega-6, omega-9 fatty acid ethyl esters and their application method. The application of this discovery includes the preparation of drugs, dietary supplements, food and daily necessities with oral health care and therapeutic effects.

Process for the preparation of a composition comprising unsaturated compounds

The present invention relates to a process for the preparation of a composition comprising unsaturated compounds, in particular polyunsaturated compounds, which comprises concentrating and purifying the compounds by contact with silicon and/or aluminium derivatives. The process of the invention represents an advantageous substitute of the usual distillation processes, coupled or not to chromatographic processes, and allows to isolate and remove polar byproducts.

LIPASE-CATALYSED ESTERIFICATION OF MARINE OIL

Marine oil compositions which contain EPA and DHA as free acids or hexyl esters are esterified with ethanol in the presence of a lipase catalyst under essentially organic solvent-free conditions and separated by distillation.

Characteristics of Lipase Modified with Water-soluble Acylating Reagents and Its Esterification Ability

Lip was modified with various hydrophobic groups, such as Z, Boc, lauroyl, and palmitoyl, using water-soluble acylating reagents.The chemical modification enhanced the dispersibility of Lip in organic solvents, and changed the substrate selectivity, which depends on the length of the carbon chain of triglycerides in hydrolytic reactions.As for the synthesis of triglycerides, Z-modified Lip catalyzed this reaction faster than unmodified Lip.Z-, Boc-, and fatty acid-modified Lips also catalyzed diverse esterification reactions including that of ethyl eicosapentaenoate, lactose oleate, and cholesterol oleate, and the yields of these reactions increased depending on the carbon number of the introducing group.