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84499-12-7

5,12-Naphthacenedione, 8-acetyl-6,11-dihydroxy-, also known as aclacinomycin A, is a chemical compound that belongs to the anthracycline class of antibiotics. It is commonly used in the medical field as an antineoplastic agent to treat various forms of cancer. Aclacinomycin A works by inhibiting DNA and RNA synthesis in cancer cells, ultimately leading to their death. It is recognized for its potent anticancer properties and is often used in combination with other chemotherapy drugs to improve treatment outcomes for patients with leukemia, lymphoma, and solid tumors.
Used in Pharmaceutical Industry:
5,12-Naphthacenedione, 8-acetyl-6,11-dihydroxyis used as an antineoplastic agent for its potent anticancer properties. It is particularly effective against leukemia, lymphoma, and solid tumors, and is often used in combination with other chemotherapy drugs to enhance treatment outcomes.
However, aclacinomycin A also comes with potential side effects such as bone marrow suppression, cardiotoxicity, and gastrointestinal issues. These side effects require careful monitoring and management during treatment to ensure the safety and well-being of patients. Despite its limitations, aclacinomycin A continues to hold promise as an important tool in the fight against cancer.

84499-12-7

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84499-12-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 84499-12-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,4,9 and 9 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 84499-12:
(7*8)+(6*4)+(5*4)+(4*9)+(3*9)+(2*1)+(1*2)=167
167 % 10 = 7
So 84499-12-7 is a valid CAS Registry Number.

84499-12-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 8-Acetyl-6,11-dihydroxy-naphthacene-5,12-dione

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:84499-12-7 SDS

84499-12-7Downstream Products

84499-12-7Relevant articles and documents

Stable lyophilized anthracycline glycosides

-

Page/Page column 7-8, (2008/06/13)

The present invention provides lyophilized and stable lyophilized anthracycline glycoside salts, in particular, the hydrochloride salt. Also, the present invention provides methods of stabilizing these anthracycline glycoside salts, and methods for producing stable lyophilized anthracycline glycoside salts, such as for example the antineoplastic compound idarubicin hydrochloride, or the compounds doxorubicin hydrochloride, and epirubicin hydrochloride.

Total synthesis of (+)-4-demethoxydaunomycin

Ayyangar, N R,Argade, A B,Mehendale, A R,Deshpande, V H

, p. 377 - 384 (2007/10/02)

Starting from commercially available dyestuff intermediate, quinizarin (6) as BCD-ring synthon for anthracycline, a key intermediate 5b has been prepared by a simple reaction sequence. (+/-)-4-Demethoxydaunomycinone (4b) has been synthesized from 5b.Further 4b was coupled with L-daunosamine derivative (24) to give the requisite α-glycoside 4a.

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