845-68-1Relevant academic research and scientific papers
Conversion of thebaine to oripavine and other useful intermediates for the semisynthesis of opiate-derived agents: Synthesis of hydromorphone
Murphy, Brennan,Snajdr, Ivan,Machara, Ales,Endoma-Arias, Mary Ann A.,Stamatatos, Theocharis C.,Cox, D. Phillip,Hudlicky, Tomas
, p. 2679 - 2687 (2014)
Thebaine was converted to oripavine in three steps by employing two different modes of protection of the diene moiety; as an iron tricarbonyl complex and as a Diels-Alder adduct with thioformyl cyanide. The two C-ring-protected thebaine derivatives were subjected to 3-O-demethylation by four different protocols, providing oripavine derivatives, which yielded oripavine after deprotection. Oripavine was then converted to hydromorphone by a three-step process of ketalization, hydrogenation, and deprotection, without the isolation of intermediates.
METHOD OF PREPARING BUPRENORPHINE
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Paragraph 0143; 0154, (2014/09/03)
An improved process for preparing buprenorphine and a method for increasing the yield of buprenorphine or a derivative thereof.
