84500-66-3Relevant academic research and scientific papers
Intramolecular hydride transfer onto arynes: Redox-neutral and transition metal-free C(sp3)-H functionalization of amines
Idiris, Fahima I. M.,Majesté, Cécile E.,Craven, Gregory B.,Jones, Christopher R.
, p. 2873 - 2878 (2018/03/23)
Transition metal-free intramolecular hydride transfer onto arynes is reported for the first time. This unique transformation is utilized in redox-neutral intermolecular α-functionalization reactions of different tertiary amines, generating C(sp3)-C(sp3/sp2/sp) bonds in a single synthetic operation. Deuterium labeling studies support initial cleavage of the α-C-H bond via intramolecular 1,5-hydride transfer onto the aryne, which leads to activation of a range of integrated pronucleophiles and ultimately affords a new approach to cross-dehydrogenative coupling reactions which utilize aryne intermediates.
Synthesis of 1-(Aminomethyl)-1,2,3,4-tetrahydroisoquinolines and Their Actions at Adrenoceptors in Vivo and in Vitro
Beaumont, David,Waigh, Roger D.,Sunbhanich, Methi,Nott, Michael W.
, p. 507 - 515 (2007/10/02)
An improved synthesis of 1-(aminomethyl)-1,2,3,4-tetrahydroisoquinolines has been developed by using aluminum hydride reduction of 1-cyano-1,2,3,4-tetrahydroisoquinolines.Three 1-(aminomethyl)-6,7-dihydroxytetrahydroisnolines
