84504-69-8

Basic information

• Product Name: Irsogladine maleate
• Synonyms: 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazinemaleate;2,4-diamino-6-(2,5-dichlorophenyl)-s-triazinmaleate;3,5-triazine-2,4-diamine,6-(2,5-dichlorophenyl)-(z)-2-butenedioate(1:1);gaslon;mn-1695;2,4-diamino-6-(2,5-dichlorophenyl)-1,3,5-triazine maleate;Irsogladin maleate;Gaslon N
• CAS NO: 84504-69-8
• Molecular Formula: C₄H₄O₄*C₉H₇Cl₂N₅
• Molecular Weight: 372.16
• Product Categories: Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 84504-69-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 181-182°C
• Boiling Point: 552.2oC at 760 mmHg
• Flash Point: 287.8oC
• Appearance: /
• Vapor Pressure: 3.07E-12mmHg at 25°C
• Storage Temp.: Desiccate at RT
• Water Solubility: Insoluble in water
• Merck: 14,5102
• CAS DataBase Reference: Irsogladine maleate(CAS DataBase Reference)
• NIST Chemistry Reference: Irsogladine maleate(84504-69-8)
• EPA Substance Registry System: Irsogladine maleate(84504-69-8)

Safety Data

• RTECS: XY5930000
• Hazardous Substances Data: 84504-69-8(Hazardous Substances Data)

Usage

Description

Irsogladine is a gastroprotective agent. It increases transfer of Lucifer yellow CH between isolated rabbit gastric epithelial cells, indicating enhanced gap junction intercellular communication (GJIC). Irsogladine (3 mg/kg) inhibits gastric mucosal lesion formation and decreases in gastric mucosal blood flow induced by monochloramine in rats, effects that can be prevented by the nitric oxide synthase inhibitor L-NAME . It also inhibits superoxide anion production induced by fMLP and increases cAMP levels in isolated human neutrophils in a concentration-dependent manner, similar to the phosphodiesterase 4 (PDE4) inhibitor rolipram .

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 84504-69-8 differently. You can refer to the following data:
1. An anti-ulcer drug.
2. antiulcerative;selective PDE4 inhibitor which also enhances gap junction intercellular communication

Biological Activity

Phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits in vitro and in vivo angiogenesis.

InChI:InChI=1/C9H7Cl2N5.C4H4O4/c10-4-1-2-6(11)5(3-4)7-14-8(12)16-9(13)15-7;5-3(6)1-2-4(7)8/h1-3H,(H4,12,13,14,15,16);1-2H,(H,5,6)(H,7,8)/b;2-1-

Upstream product

• 110-16-7 maleic acid 
• 57381-26-7 irsogladine 

Downstream Products

• 57381-26-7 irsogladine 

Relevant articles and documents

Irsogladine maleate preparation method

The invention belongs to the field of organic matter synthesis, and particularly relates to an irsogladine maleate preparation method, wherein p-dichlorobenzene is used as a starting raw material, andfive reactions of acetylation, bromoform reaction, cyanation, cyclization and salt formation are performed to prepare the target compound. According to the present invention, the new irsogladine maleate preparation method is used, can significantly accelerate the reaction rate and improve the yield, has advantages of cost reducing, environment protection, simple operation and convenient post-treatment, and is suitable for industrial production.