84519-07-3

Upstream product

• 76247-40-0 chloromethyl penicillanate 1,1-dioxide 
• 69388-84-7 sodium sulbactam 
• 102985-65-9 potassium 6-(2-benzyloxycarbonylamino-2phenylacetamido)penicillanate 

Relevant academic research and scientific papers

Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide

Process for preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide of the formula STR1 where X is Cl, Br, I, certain alkylsulfonyloxy or arylsulfonyloxy groups, useful as intermediates in production of antibiotics having beta-lactamase activity, which comprises hydrogenolysis of an ester of the formula STR2 where n is zero, 1 or 2; Y and Z are each Cl, Br or I, or Y is H and Z is Cl, Br, I, C N-- or SCN--, or Y is arylselenyl and Z is Cl or Br; and when n is zero or 1, oxidation of the hydrogenolysis product; a process for preparing compounds of formula (VI, n=2) by oxidation of the corresponding compound (VI) wherein n is zero or 1, and certain novel intermediates useful in the above processes.

Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide

6'-Acylaminopenicillanoyloxymethyl esters of penicillanic acid 1,1-dioxide are useful as antibacterial agents. The 6'-aminopenicillanoyloxymethyl ester, halomethyl esters, alkylsulfonyloxymethyl esters and arylsulfonyloxymethyl esters of penicillanic acid 1,1-dioxide are all useful intermediates for the aforesaid antibacterial agents.