84520-68-3

Basic information

• Product Name: 1-tert-butyl 2-Methyl 4-azidopyrrolidine-1,2-dicarboxylate
• Synonyms: 1-tert-butyl 2-Methyl 4-azidopyrrolidine-1,2-dicarboxylate;(2S,4S)-1-tert-butyl 2-Methyl 4-azidopyrrolidine-1,2-dicarboxylate;1,2-Pyrrolidinedicarboxylic acid, 4-azido-, 1-(1,1-dimethylethyl)2-methyl ester, (2S,4S)-;BJQMWOSPZUZYNW-YUMQZZPRSA-N
• CAS NO: 84520-68-3
• Molecular Formula: C₁₁H₁₈N₄O₄
• Molecular Weight: 270.28502
• Mol File: 84520-68-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-tert-butyl 2-Methyl 4-azidopyrrolidine-1,2-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-tert-butyl 2-Methyl 4-azidopyrrolidine-1,2-dicarboxylate(84520-68-3)
• EPA Substance Registry System: 1-tert-butyl 2-Methyl 4-azidopyrrolidine-1,2-dicarboxylate(84520-68-3)

Safety Data

• Hazardous Substances Data: 84520-68-3(Hazardous Substances Data)

Usage

Uses

Boc-L-cis-4-azidoproline Methyl Ester is used as a reagent for preparation of antibacterial and anti-TB tat-peptidomimetics with improved efficacy and half-life

Upstream product

• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 

Downstream Products

• 922139-40-0 tert-butyl (2S,4S)-4-amino-2-(hydroxymethyl)pyrrolidin-1-carboxylate 
• 113451-59-5 (1S,4S)-2,5-Diaza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester 
• 1369573-39-6 C₅₁H₆₇N₁₃O₁₁ 
• 1369573-38-5 C₅₀H₆₅N₁₃O₁₁ 
• 1369573-37-4 C₄₉H₆₃N₁₃O₁₁ 
• 1369573-36-3 C₄₈H₆₁N₁₃O₁₁ 
• 1203557-04-3 C₅₂H₆₉N₁₃O₁₁ 
• 1203557-03-2 C₅₁H₆₇N₁₃O₁₁ 
• 1203557-02-1 C₅₀H₆₅N₁₃O₁₁ 
• 1203557-01-0 C₄₉H₆₃N₁₃O₁₁ 
• 1369573-35-2 C₆₃H₈₃N₁₁O₁₁ 
• 1369573-34-1 C₆₂H₈₁N₁₁O₁₁ 
• 1203557-00-9 C₆₂H₈₁N₁₁O₁₂ 
• 1369573-33-0 C₆₂H₈₁N₁₁O₁₁ 

Relevant articles and documents

Altering the sex pheromone cyclo(L-pro-l-pro) of the diatom seminavis robusta towards a chemical probe

As a major group of algae, diatoms are responsible for a substantial part of the primary production on the planet. Pennate diatoms have a predominantly benthic lifestyle and are the most species-rich diatom group, with members of the raphid clades being motile and generally having heterothallic sexual reproduction. It was recently shown that the model species Seminavis robusta uses multiple sexual cues during mating, including cyclo(L-Pro-L-Pro) as an attraction pheromone. Elaboration of the pheromone-detection system is a key aspect in elucidating pennate diatom life-cycle regulation that could yield novel fundamental insights into diatom speciation. This study reports the synthesis and bio-evaluation of seven novel pheromone analogs containing small structural alterations to the cyclo(L-Pro-L-Pro) pheromone. Toxicity, attraction, and interference assays were applied to assess their potential activity as a pheromone. Most of our analogs show a moderate-to-good bioactivity and low-to-no phytotoxicity. The pheromone activity of azide-and diazirine-containing analogs was unaffected and induced a similar mating behavior as the natural pheromone. These results demonstrate that the introduction of confined structural modifications can be used to develop a chemical probe based on the diazirine-and/or azide-containing analogs to study the pheromone-detection system of S. robusta.

HEPATITIS C VIRUS INHIBITORS

The invention provides compounds of formula (I): wherein the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are inhibitors of replication of the hepatitis C virus. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat hepatitis C viral infections, and processes and intermediates useful for preparing such compounds.

Synthesis and biological activity of 1-phenylsulfonyl-4-phenylsulfonylaminopyrrolidine derivatives as thromboxane A2 receptor antagonists

The synthesis and biological activity of novel 1-phenylsulfonyl-4- phenylsulfonylaminopyrrolidine analogues are described. All compounds were produced through modification of the substituent formally corresponding to the 1,3-dioxane ring system and the ω-octenol side chain of thromboxane A2 (TXA2), in reference to the structure of Daltroban. Several compounds were found to be potent TXA2 receptor antagonists. Compound 51a was the most effective inhibitor of 9,11-epoxymethano PGH2 (U-46619)-induced rat aortic strip contraction (IC50 = 0.48 nM).