845258-50-6Relevant academic research and scientific papers
A challenging synthesis of new 1,3,4-thiadiazole derivatives starting from 2-acylamino-3,3-dichloroacrylonitriles
Golovchenko, Oleksandr V.,Pilyo, Stepan G.,Brovarets, Vladimir S.,Chernega, Alexander N.,Drach, Boris S.
, p. 454 - 458 (2007/10/03)
Available 2-acylamino-3,3-dichloro-acrylonitriles, when treated with hydrazine hydrate, provide 2-alkyl- or 2-aryl-5-hydrazino-1,3-oxazole-4- carbonitriles that readily add alkyl or aryl isothio-cyanates and the adducts formed recyclize on heating. Finally, the synthesis results in 5-alkyl(aryl)amino-1,3,4-thiadiazol-2-yl(acylamino)acetonitriles or the products of their further cyclization, 2-(5-amino-1,3-oxazol-2-yl)-1,3,4-thiadiazole derivatives. The structures of the novel substituted 1,3,4-thiadiazoles are corroborated spectroscopically as well as by X-ray diffraction method.
