845267-57-4 Usage
Uses
Used in Pharmaceutical and Agrochemical Synthesis:
2-BROMO-1-PYRIMIDIN-4-YL-ETHANONE HYDROBROMIDE is utilized as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides.
Used in Organic Synthesis as a Reagent:
In the field of organic synthesis, 2-BROMO-1-PYRIMIDIN-4-YL-ETHANONE HYDROBROMIDE serves as a valuable reagent, facilitating a range of chemical reactions and transformations.
Used in the Development of New Materials:
2-BROMO-1-PYRIMIDIN-4-YL-ETHANONE HYDROBROMIDE is employed in the creation of innovative materials for a variety of applications, showcasing its versatility in material science.
Used in Medicinal Chemistry and Drug Discovery:
2-BROMO-1-PYRIMIDIN-4-YL-ETHANONE HYDROBROMIDE is leveraged in medicinal chemistry and drug discovery processes, where it aids in the design and synthesis of potential therapeutic agents.
Safety and Handling:
Given its classification as a hazardous material, 2-BROMO-1-PYRIMIDIN-4-YL-ETHANONE HYDROBROMIDE must be handled and stored in accordance with established safety and handling protocols to ensure the protection of both individuals and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 845267-57-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,5,2,6 and 7 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 845267-57:
(8*8)+(7*4)+(6*5)+(5*2)+(4*6)+(3*7)+(2*5)+(1*7)=194
194 % 10 = 4
So 845267-57-4 is a valid CAS Registry Number.
845267-57-4Relevant academic research and scientific papers
Cdc7 kinase inhibitors: Pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships
Vanotti, Ermes,Amici, Raffaella,Bargiotti, Alberto,Berthelsen, Jens,Bosotti, Roberta,Ciavolella, Antonella,Cirla, Alessandra,Cristiani, Cinzia,D'Alessio, Roberto,Forte, Barbara,Isacchi, Antonella,Martina, Katia,Menichincheri, Maria,Molinari, Antonio,Montagnoli, Alessia,Orsini, Paolo,Pillan, Antonio,Roletto, Fulvia,Scolaro, Alessandra,Tibolla, Marcellino,Valsasina, Barbara,Varasi, Mario,Volpi, Daniele,Santocanale, Corrado
, p. 487 - 501 (2008/09/18)
Cdc7 kinase is an essential protein that promotes DNA replication in eukaryotic organisms. Genetic evidence indicates that Cdc7 inhibition can cause selective tumor-cell death in a p53-independent manner, supporting the rationale for developing Cdc7 small-molecule inhibitors for the treatment of cancers. In this paper, the synthesis and structure-activity relationships of 2-heteroaryl-pyrrolopyridinones, the first potent Cdc7 kinase inhibitors, are described. Starting from 2-pyridin-4-yl-1,5,6,7-tetrahydro-pyrrolo[3,2-c] pyridin-4-one, progress toward a simple scaffold, tailored for Cdc7 inhibition, is reported.
