845267-74-5

Upstream product

• 15099-85-1 3(S)-amino-4-phenylbutyric acid 
• 845538-58-1 tert-butyl 1-benzyl-3-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)-3-oxopropylcarbamate 
• 120378-17-8 threo-(2RS)-3-t-butoxycarbonylamino-4-phenylbutanoic acid 

Relevant academic research and scientific papers

ISOQUINOLINOPYRROLOPYRIDINONES ACTIVE AS KINASE INHIBITORS

Heteroarylpyridinone derivatives represented by formula (I) wherein R1, R2, R3, R4, R5, and X are as defined in the specification, compositions thereof, and methods of use thereof. Particularly, there are described isoquinolinoyrrolopyridinones, pharmaceutical compositions comprising them and their use as therapeutic agents in the treatment of cancer and cell proliferation disorders.

N-substituted pyrrolopyridinones active as kinase inhibitors

Compounds represented by formula (I) wherein A, R1, R2, R3, R4, R5, and R6 are as defined in the specification, pharmaceutical compositions thereof, and methods of use thereof.

PYRIDYLPYRROLE DERIVATIVES ACTIVE AS KINASE INHIBITORS

Pyridylpyrrole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treat