84532-34-3Relevant academic research and scientific papers
Crystalline 3-hydroxycephalosporin solvates
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, (2008/06/13)
4'-Nitrobenzyl 7-phenoxyacetamide-3-hydroxy-3-cephem-4-carboxylate forms crystalline solvates with acetic acid, propionic acid and methylene chloride. The corresponding 3-hydroxy-3-cephem sulfoxide forms crystalline solvates with acetic acid, propionic acid and methanol. The described solvates allow for facile isolation and purification of 4'-nitrobenzyl 7-phenoxyacetamido-3-hydroxy-3-cephem-4-carboxylate and its 1-oxide.
Process for the manufacture of 7β-amino-3-cephem-3-ol-4 carboxylic acid compounds
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, (2008/06/13)
7β-amino-3-cephem-3-ol-4-carboxylic acid compounds of the formula STR1 wherein R1a represents hydrogen or an amino protective group R1A and R1B represents hydrogen or an acyl group Ac, or R1a and R1b together represent a bivalent amino protective group, R2 represents hydroxyl or a radical R2A which together with the carbonyl grouping --C(=O)-- forms a protected carboxyl group and R3 represents hydrogen, lower alkyl or a hydroxyl protective group, and 1-oxides or 3-cephem compounds of the formula IA, and the corresponding 2-cephem compounds are prepared in that a compound of the formula STR2 wherein R1a, R1b and R2A have the meanings mentioned under formula IA, R3o represents lower alkyl or a hydroxyl protective group and Y represents a group which is removed, is treated with a base; also comprised are intermediate products.
