84540-52-3Relevant articles and documents
Synthesis of substituted benzenes and phenols by ring-closing olefin metathesis
Yoshida, Kazuhiro,Takahashi, Hidetoshi,Imamoto, Tsuneo
experimental part, p. 8246 - 8261 (2009/09/29)
New synthetic approaches to substituted aromatic compounds are reported. Ring-closing olefin metathesis (RCM)/dehydration and RCM/tautomerization are the key processes in the synthesis of substituted benzenes 3 and phenols 6, respectively. Readily accessible 1,5,7-trien-4-ols 7, which are the precursors of benzenes, were prepared from β-halo-α, β-unsaturated aldehydes 11 or β-halo-α,β-unsaturated esters 19 by utilizing reliable transformations in which cross-coupling with vinylic metal reagents 12 and allylation with allylic metal reagents 13 were employed as carbon-carbon bond forming reactions. RCM of 7, followed by dehydration, afforded a wide variety of substituted benzenes 3. In addition, RCM of 1,5,7trien-4-ones 9, which were prepared by oxidation of 7, furnished various substituted phenols 6 by automatic tautomerization.
The Generation of 2-Vinylcyclopentene-1,3-diones via a Five-Component Coupling in the Coordination Sphere of Chromium
Xu, Yao-Chang,Challener, Cynthia A.,Dragisich, Vera,Brandvold, Timothy A.,Peterson, Glen A.,et al.
, p. 7269 - 7271 (2007/10/02)
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