84547-85-3

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-1-methyl-1H-pyrazole-3-carboxylic acid is used as a reagent for the preparation of a library of acylaminoacrylates. These acylaminoacrylates are employed in fragment-based identification of selective small molecule covalent inhibitors of the cysteine protease papain. This enzyme plays a crucial role in various biological processes, and its inhibition can be beneficial in treating certain diseases.
Used in Chemical Synthesis:
4-Chloro-1-methyl-1H-pyrazole-3-carboxylic acid is used as a building block in the synthesis of various organic compounds. Its unique structure allows for the formation of diverse chemical entities, making it a valuable component in the development of new pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Research and Development:
4-Chloro-1-methyl-1H-pyrazole-3-carboxylic acid is utilized in research and development laboratories for the study of its chemical properties and potential applications. It can be used to investigate the reactivity of various functional groups and to develop new synthetic routes for the preparation of complex organic molecules.

InChI:InChI=1/C5H5ClN2O2/c1-8-2-3(6)4(7-8)5(9)10/h2H,1H3,(H,9,10)

Upstream product

• 15878-44-1 1,3-Dimethyl-4-chlor-pyrazol 
• 25016-20-0 1-methylpyrazole-3-carboxylic acid 
• 694-48-4 1,3-dimethyl-1H-pyrazole 
• 942853-19-2 ethyl 4-chloro-1-methyl-pyrazole-3-carboxylate 

Downstream Products

• 1005785-54-5 4-chloro-N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-fluorophenyl]-1-methyl-1H-pyrazole-3-carboxamide 
• 1005785-52-3 4-chloro-N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1-methyl-1H-pyrazole-3-carboxamide 
• 1259931-94-6 C₃₈H₄₀ClF₂N₇O₂ 
• 1310347-64-8 4-chloro-1-methyl-1H-pyrazole-3-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide 

Relevant academic research and scientific papers

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same. The compounds include an IRAK binding moiety capable of binding to IRAK4 and a degradation inducing moiety (DIM). The DIM could be DTM a ligase binding moiety (LBM) or lysine mimetic. The compounds could be useful as IRAK protein kinase inhibitors and applied to IRAK mediated disorders.

PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR

The present invention relates to processes for preparing pyrazole derivatives of Formula (I) and salts and pharmaceutical compositions of the salts thereof, useful as modulators of 5-HT2A serotonin receptor activity. The present invention also relates to intermediates used in the processes, and their preparation. The present invention also relates to salts of compounds of Formula (I) and pharmaceutical compositions thereof

Electrosynthesis of 4-chloropyrazolecarboxylic acids

4-Chlorosubstituted pyrazolecarboxylic acids were synthesized via chlorination of the corresponding acids at the Pt anode in NaCl aqueous solutions under conditions of divided galvanostatic electrolysis. The efficiency of the process depends on the structures of the initial pyrazolecarboxylic acids, particularly, on the donor-acceptor properties of the substituents and on their position in the pyrazole ring. The yields of the 4-chlorosubstituted products of chlorination of pyrazole-3(5)-carboxylic acid, 1-methylpyrazole-5- carboxylic acid, 1-methyl-pyrazole-3-carboxylic acid, 1-ethylpyrazole-3- carboxylic acid, and 1-methyl-3-nitropyrazole- 5-carboxylic acid are 92, 93, 69, 80, and 4%, respectively.