845543-66-0

Basic information

• Product Name: 1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-2-amino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-, 1,1-dimethylethyl ester, (2R)-
• CAS NO: 845543-66-0
• Molecular Formula: C18H26F2N2O3
• Molecular Weight: 356.413
• Mol File: 845543-66-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-2-amino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-, 1,1-dimethylethyl ester, (2R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-2-amino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-, 1,1-dimethylethyl ester, (2R)-(845543-66-0)
• EPA Substance Registry System: 1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-2-amino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-, 1,1-dimethylethyl ester, (2R)-(845543-66-0)

Safety Data

• Hazardous Substances Data: 845543-66-0(Hazardous Substances Data)

Upstream product

• 1221264-41-0 (S)-2-amino-3-(3,5-difluorophenyl)-N-methoxy-N-methylpropanamide 
• 1221264-42-1 (S)-2-(dibenzylamino)-3-(3,5-difluorophenyl)-N-methoxy-N-methylpropanamide 
• 1221264-43-2 (R)-tert-butyl 2-((1S,2S)-2-(dibenzylamino)-3-(3,5-difluorophenyl)-1-hydroxypropyl)pyrrolidine-1-carboxylate 
• 362480-01-1 (S)-tert-butyl 3-(3,5-difluorophenyl)-1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate 
• 845543-61-5 (S)-N,N-dibenzyl-3,5-difluorophenyl-alaninal 
• 845543-65-9 C₃₃H₃₈F₂N₂O₅ 

Downstream Products

• 845543-78-4 C₂₉H₄₃F₂N₃O₅ 
• 845543-77-3 C₂₉H₄₃F₂N₃O₅ 

Relevant articles and documents

COMPOUNDS CONTAINING FUSED RINGS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF

The invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating Alzheimer's disease.

CYCLIC AMINE BACE-1 INHIBITORS HAVING A BENZAMIDE SUBSTITUENT

Disclosed are compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R is-C(O)-N(R27)(R28) or and the remaining variables are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of treating cognitive or neurodegenerative diseases such as Alzheimer’s disease. Also disclosed are pharmaceutical compositions and methods of treating cognitive or neurodegenerative diseases comprising the compounds of formula I in combination with a β-secretase inhibitor other than those of formula I, an HMG-CoA reductase inhibitor, a gamma-secretase inhibitor, a non-steroidal anti-inflammatory agent, and N-methyl-D-aspartate receptor antagonist, a cholinesterase inhibitor or an anti-amyloid antibody.