845550-71-2Relevant articles and documents
Convergent Synthesis of Immune Inhibitor IMMH002
Chen, Si,Shi, Zeyu,Xiao, Qiong,Yin, Dali
, p. 1174 - 1180 (2020/10/30)
A convergent synthesis of IMMH002 in 36% overall yield starting from bromobenzene is described with a key Suzuki-Miyaura cross-coupling reaction used to provide a crucial intermediate. The route does not require column chromatography and solves the most intractable quality problem caused by a homologue by-product in the original linear synthesis. Furthermore, reducing the use of Lewis acid mediated reactions improves the environmental impact of the synthesis and reduces overall waste. The new route described herein is more efficient, convenient, reliable, and economically more viable when compared to the previously reported linear route.
Preparation method of aituomode
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Paragraph 0064; 0066; 0070, (2020/05/29)
The invention discloses a preparation method of aituomode. Bromo-benzene is used as an initial raw material to prepare aituomode by adopting a convergent synthesis route. The yield of the preparationmethod is high, the cost is low, the amount of generated waste water, waste gas, and waste solids is low, the operation is convenient, and the application value is high.
Preparation method of pusaimode (Chinese name)
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Paragraph 0054; 0055; 0056; 0060, (2020/05/29)
The invention discloses a preparation method of pusaimode. Bromo-benzene and benzene are used as initial raw materials to prepare pusaimode by adopting a convergent synthesis route. The yield of the preparation method is high, the cost is low, the amount of generated waste water, waste gas, and waste solids is low, the operation is convenient, and the application value is high.
