845552-64-9Relevant academic research and scientific papers
Discovery of small-molecule nonpeptide antagonists of nociceptin/orphanin FQ receptor: The studies of design, synthesis, and structure-Activity relationships for (4-Arylpiperidine substituted-methyl)-[bicyclic (hetero)cycloalkanobenzene] derivatives
Hayashi, Shigeo,Ohashi, Katsuyo,Mihara, Sachiko,Nakata, Eriko,Emoto, Chie,Ohta, Atsuko
, p. 345 - 364 (2016)
Nociceptin/orphanin FQ (N/OFQ) and N/OFQ peptide (NOP) receptor are expressed and distributed in various regions such as central nervous system (CNS), peripheral nervous system, immune system, and peripheral tissues. N/OFQ and NOP receptor have important
TETRAHYDROISOQUINOLINE OR ISOCHROMAN COMPOUNDS AS ORL-1 RECEPTOR LIGANDS FOR THE TREATMENT OF PAIN AND CNS DISORDERS
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Page/Page column 51, (2010/02/10)
This invention provides the compounds of formula (I), or its a pharmaceutically acceptable ester or amide of such compound, or a pharmaceutically acceptable salt thereof, wherein X1 is NH; R1, R2, R4 through Rs
