845616-08-2

Upstream product

• 90222-79-0 2-amino-5-(methylsulfonyl)benzoic acid 

Downstream Products

• 847547-02-8 2-cyclohex-1-enyl-5-methanesulfonyl-benzoic acid 
• 847547-25-5 4-[4-(2-Iodo-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-benzonitrile 
• 847547-18-6 4-(methylsulfonyl)-[1,1′-biphenyl]-2-carboxylic acid 
• 847547-04-0 2-cyclohept-1-enyl-5-methanesulfonyl-benzoic acid 
• 847547-03-9 2-cyclopent-1-enyl-5-methanesulfonyl-benzoic acid 
• 847547-09-5 2-Iodo-5-methanesulfonyl-benzoic acid methyl ester 
• 847547-05-1 2-(3,6-Dihydro-2H-pyran-4-yl)-5-methanesulfonyl-benzoic acid 
• 845616-07-1 (2-Iodo-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone 

Relevant academic research and scientific papers

Sulfanyl substituted phenyl methanones

The present invention relates to compounds of formula I wherein R1, R2, R3, X, X1, and n are as defined in the specification and pharmaceutically acceptable acid addition salts thereof. These compounds are good inhibitors of the glycine transporter 1 (GlyT-1) for the treatment CNS disorders, such as schizophrenia, cognitive impairment, and Alzheimer's disease.

Substituted phenyl methanones

The present invention relates to compounds of general formula IA or IB wherein X1 and X2 are each independently N or C—R″ and R1, R2,R3, R4, R5, and R6 are as defined

Heterocyclic-substituted phenyl methanones

The present invention relates to compounds of formula I wherein R1, R2, and are defined in the specification and to pharmaceutically acceptable acid addition salts thereof.

Substituted acylpiperazine derivatives

The invention relates to compounds of formula wherein the substituents are as defined in the specification and to pharmaceutically acceptable acid addition salts thereof. The invention further relates to methods for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.

1- (2-AMINO-BENZOL) -PIPERAZINE DERIVATIVES AS GLYCINE UPTAKE INHIBITORS FOR THE TREATMENT OF PSYCHOSES

A compound of formula (I) wherein the substituents are described in claim 1 for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.

BENZOYL-PIPERAZINE DERIVATIVES

The invention relates to compounds of formula wherein the substituents are described herein. The compounds may be used in the treatment of illnesses based on the glycine uptake inhibitor, such as psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.