845616-81-1

Basic information

• Product Name: 1-(3-Fluoro-5-trifluoroMethylpyridin-2-yl)piperazine
• Synonyms: 1-(3-Fluoro-5-trifluoroMethylpyridin-2-yl)piperazine;1-(3-Fluoro-5-trifluoroMethylpyridin-2-yl)
• CAS NO: 845616-81-1
• Molecular Formula: C₁₀H₁₁F₄N₃
• Molecular Weight: 249.2080528
• Mol File: 845616-81-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 308.9±42.0 °C(Predicted)
• Appearance: /
• Density: 1.320±0.06 g/cm3(Predicted)
• PKA: 8.24±0.10(Predicted)
• CAS DataBase Reference: 1-(3-Fluoro-5-trifluoroMethylpyridin-2-yl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-Fluoro-5-trifluoroMethylpyridin-2-yl)piperazine(845616-81-1)
• EPA Substance Registry System: 1-(3-Fluoro-5-trifluoroMethylpyridin-2-yl)piperazine(845616-81-1)

Safety Data

• Hazardous Substances Data: 845616-81-1(Hazardous Substances Data)

Usage

General Description

1-(3-Fluoro-5-trifluoroMethylpyridin-2-yl)piperazine is a chemical compound that belongs to the class of piperazine derivatives. It is characterized by the presence of a piperazine ring linked to a pyridine ring with a fluorine atom and a trifluoromethyl group attached to the pyridine ring. 1-(3-Fluoro-5-trifluoroMethylpyridin-2-yl)piperazine is commonly used in medicinal chemistry as a building block for the synthesis of various pharmaceuticals, particularly in the development of potential therapeutic agents for a range of diseases and disorders. Its unique structural features make it a valuable tool for drug discovery and development, with potential applications in the fields of neuroscience, oncology, and infectious diseases. Additionally, it may also have uses in other industrial and research settings due to its diverse pharmacological properties and structural versatility.

Upstream product

• 110-85-0 piperazine 
• 89402-42-6 2,3-difluoro-5-(trifluoromethyl)pyridine 
• 72600-67-0 2-chloro-3-fluoro-5-(trifluoromethyl)pyridine 
• 72587-15-6 2-chloro-3-nitro-5-(trifluoromethyl)pyridine 
• 897376-76-0 4-(3-fluoro-5-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1055353-53-1 C₂₀H₂₁F₄N₃O₄S 
• 845614-11-1 Bitopertin 

Relevant articles and documents

MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2

The present application provides a compound of Formula: or a pharmaceutically acceptable salt thereof, wherein ring B, L1, ring A, L2, n, R1, R2, R3, R4, and X1 are as described herein. Pharmaceutical compositions comprising the compound, as well as the methods of making and using the compound, are also provided.

Selective GlyT1 inhibitors: Discovery of [4-(3-fluoro-5- trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2, 2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a promising novel medicine to treat schizophrenia

The GlyT1 transporter has emerged as a key novel target for the treatment of schizophrenia. Herein, we report on the optimization of the 2-alkoxy-5-methylsulfonebenzoylpiperazine class of GlyT1 inhibitors to improve hERG channel selectivity and brain penetration. This effort culminated in the discovery of compound 10a (RG1678), the first potent and selective GlyT1 inhibitor to have a beneficial effect in schizophrenic patients in a phase II clinical trial.

CAMPHOR-DERIVED CXCR3 ANTAGONISTS

The instant invention related to camphor derivatives of which are useful in treating diseases wherein inhibition of the exzyme CXCR3 results in beneficial therapy in a mammal.