845618-08-8

Basic information

• Product Name: 5-Chloro-2-trifluoromethyl-pyrimidine
• Synonyms: 5-Chloro-2-trifluoromethyl-pyrimidine
• CAS NO: 845618-08-8
• Molecular Formula: C₅H₂ClF₃N₂
• Molecular Weight: 182.53
• Mol File: 845618-08-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-Chloro-2-trifluoromethyl-pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-2-trifluoromethyl-pyrimidine(845618-08-8)
• EPA Substance Registry System: 5-Chloro-2-trifluoromethyl-pyrimidine(845618-08-8)

Safety Data

• Hazardous Substances Data: 845618-08-8(Hazardous Substances Data)

Usage

General Description

5-Chloro-2-trifluoromethyl-pyrimidine is a chemical compound with the molecular formula C5H2ClF3N2. It is a heterocyclic aromatic organic compound that contains both chlorine and fluorine atoms. 5-Chloro-2-trifluoromethyl-pyrimidine is commonly used in the pharmaceutical industry as a building block for the synthesis of various pharmaceuticals, agrochemicals, and other fine chemicals. It is also used as a reagent in organic synthesis and has been reported to exhibit antiviral and antibacterial activity. 5-Chloro-2-trifluoromethyl-pyrimidine is a colorless to pale yellow liquid with a pungent odor and is considered to be a hazardous chemical, requiring careful handling and storage.

Upstream product

• 354-37-0 trifluoroacetamidine 
• 874676-81-0 5-chloro-2-iodopyrimidine 

Downstream Products

• 845618-09-9 4-(2-trifluoromethyl-pyrimidin-5-yl)-piperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Trifluoromethylation of haloarenes with a new trifluoro-methylating reagent Cu(O2CCF2SO2F)2

A new trifluoromethylating reagent Cu(O2CCF2SO2F)2, which easily decomposes to generate active CuCF3 species in DMF at room temperature, has been conveniently prepared from inexpensive starting materials on a large scale. This new reagent can be applied to efficiently trifluoromethylate a variety of haloarenes under mild conditions, providing good-to-excellent yields of the desired products.

Phenyl derivatives comprising an acetylene group

This invention is concerned with compounds of the formula I: wherein one of R5, R6 and R7 is and X1, X2, R1 to R12, m, n and o are as defined in the description, and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.