845618-08-8

Basic information

• Product Name: 5-Chloro-2-trifluoromethyl-pyrimidine
• Synonyms: 5-Chloro-2-trifluoromethyl-pyrimidine
• CAS NO: 845618-08-8
• Molecular Formula: C₅H₂ClF₃N₂
• Molecular Weight: 182.53
• Mol File: 845618-08-8.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-Chloro-2-trifluoromethyl-pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-2-trifluoromethyl-pyrimidine(845618-08-8)
• EPA Substance Registry System: 5-Chloro-2-trifluoromethyl-pyrimidine(845618-08-8)

Safety Data

• Hazardous Substances Data: 845618-08-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Chloro-2-trifluoromethyl-pyrimidine is utilized as a building block for the synthesis of a wide range of pharmaceuticals, agrochemicals, and other fine chemicals. Its unique structure and functional groups make it a valuable component in the development of new drugs and chemical compounds.
Used in Organic Synthesis:
As a reagent in organic synthesis, 5-Chloro-2-trifluoromethyl-pyrimidine plays a crucial role in the formation of various chemical compounds. Its versatility and reactivity contribute to the synthesis of complex organic molecules for research and industrial applications.
Used in Antiviral and Antibacterial Applications:
5-Chloro-2-trifluoromethyl-pyrimidine has been reported to exhibit antiviral and antibacterial activity, making it a potential candidate for the development of new therapeutic agents to combat viral and bacterial infections.

Upstream product

• 354-37-0 trifluoroacetamidine 
• 874676-81-0 5-chloro-2-iodopyrimidine 

Downstream Products

• 845618-09-9 4-(2-trifluoromethyl-pyrimidin-5-yl)-piperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Trifluoromethylation of haloarenes with a new trifluoro-methylating reagent Cu(O2CCF2SO2F)2

A new trifluoromethylating reagent Cu(O2CCF2SO2F)2, which easily decomposes to generate active CuCF3 species in DMF at room temperature, has been conveniently prepared from inexpensive starting materials on a large scale. This new reagent can be applied to efficiently trifluoromethylate a variety of haloarenes under mild conditions, providing good-to-excellent yields of the desired products.

Selective GlyT1 inhibitors: Discovery of [4-(3-fluoro-5- trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2, 2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a promising novel medicine to treat schizophrenia

The GlyT1 transporter has emerged as a key novel target for the treatment of schizophrenia. Herein, we report on the optimization of the 2-alkoxy-5-methylsulfonebenzoylpiperazine class of GlyT1 inhibitors to improve hERG channel selectivity and brain penetration. This effort culminated in the discovery of compound 10a (RG1678), the first potent and selective GlyT1 inhibitor to have a beneficial effect in schizophrenic patients in a phase II clinical trial.

Phenyl derivatives comprising an acetylene group

This invention is concerned with compounds of the formula I: wherein one of R5, R6 and R7 is and X1, X2, R1 to R12, m, n and o are as defined in the description, and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.