84565-28-6Relevant academic research and scientific papers
Photocatalytic α-Tertiary Amine Synthesis via C?H Alkylation of Unmasked Primary Amines
Alder, Catherine M.,Ballantyne, George,Cresswell, Alexander J.,Cunningham, William B.,Edwards, Lee J.,Grayson, Matthew N.,Kinsella, Anna G.,McKay, Blandine S. J.,Mules, Tom,Ryder, Alison S. H.,Turner-Dore, Jacob
supporting information, p. 14986 - 14991 (2020/06/20)
A practical, catalytic entry to α,α,α-trisubstituted (α-tertiary) primary amines by C?H functionalisation has long been recognised as a critical gap in the synthetic toolbox. We report a simple and scalable solution to this problem that does not require any in situ protection of the amino group and proceeds with 100 percent atom-economy. Our strategy, which uses an organic photocatalyst in combination with azide ion as a hydrogen atom transfer (HAT) catalyst, provides a direct synthesis of α-tertiary amines, or their corresponding γ-lactams. We anticipate that this methodology will inspire new retrosynthetic disconnections for substituted amine derivatives in organic synthesis, and particularly for challenging α-tertiary primary amines.
Cyclopropylidenecyclanes Oxydation par l'acide peroxycarboximidique
Bertrand, Marcel,Meou, Alain,Tubul, Arlette
, p. 3691 - 3694 (2007/10/02)
The title reaction gives a mixture of four compounds .A 2-cyclohexyllideneoxetane is invoked as intermediary to account for the unusual lactone formation.
