845658-50-6Relevant academic research and scientific papers
NOVEL PYRIMIDINE DERIVATIVE FOR INHIBITING THE GROWTH OF CANCER CELLS
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Page/Page column 48, (2011/09/15)
The present invention provides a novel pyrimidine derivative or pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising same, which can effectively inhibit the growth of cancer cells induced by the overexpression of EGFR incl
Alkynyl pyrimidines as dual EGFR/ErbB2 kinase inhibitors
Waterson, Alex G.,Stevens, Kirk L.,Reno, Michael J.,Zhang, Yue-Mei,Boros, Eric E.,Bouvier, Frederic,Rastagar, Abdullah,Uehling, David E.,Dickerson, Scott H.,Reep, Bryan,McDonald, Octerloney B.,Wood, Edgar R.,Rusnak, David W.,Alligood, Krystal J.,Rudolph, Sharon K.
, p. 2419 - 2422 (2007/10/03)
Anilinoalkynylpyrimidines were prepared and evaluated as dual EGFR/ErbB2 kinase inhibitors. A preference was found for substituted phenyl and heteroaromatic rings attached to the alkyne. In addition, the presence of a potential hydrogen bond donor appende
CHEMICAL COMPOUNDS
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Page/Page column 60, (2010/02/10)
The present invention discloses pyrimidine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such pyrimidine derivatives are useful in the treat
