84570-79-6Relevant academic research and scientific papers
A convenient access to 2,4-disubstituted quinazolines via one-pot three-component reaction under mild conditions?
Bose, D. Subhas,Ramesh, Nukala
supporting information, p. 1495 - 1503 (2020/04/27)
A new and practical method has been developed for the synthesis of 2,4-disubstituted quinolines via one-pot three-component reaction of o-amino arylketones, aldehydes and ammonium acetate in high yields by using DDQ in CH3CN under mild conditio
Palladium-Catalyzed Cross-Coupling of 4-Tosyloxyquinazolines with Organoindium Reagents: An Efficient Route to 4-Substituted Quinazolines
Ye, Xinglin,Yuan, Jianjun,Zhou, Yirong,Deng, Zhihong,Mao, Xuechun,Peng, Yiyuan
, p. 3976 - 3984 (2016/11/11)
An efficient route to 4-substituted quinazolines by arylation or alkylation of quinazolinones under mild conditions is described. 4-Tosyloxyquinazolines were obtained through the reaction of quinazolinones and p-methylbenzenesulfonyl chloride in the presence of K2CO3. The cross-coupling reaction of 4-tosyloxyquinazolines with organoindium reagents, carried out in tetrahydrofuran, catalyzed by Pd2(dba)3/ (2-furyl)3P led to the formation of 4-functionalized quinazolines in good to excellent yields. Higher yields were obtained by the one-pot reaction of quinazolinone, p-methylbenzenesulfonyl chloride, Pd2(dba)3-/(2-furyl)3P, and organoindium reagent. These methods using organoindium compounds as coupling partners provided an efficient route to 4-(hetero)aryl/alkylquinazolines, especially 4-substituted quinazolines bearing a halogen scaffold.
Nickel-catalyzed Kumada Cross-coupling Reaction for the Synthesis of 2,4-Diarylquinazolines
Ye, Xinglin,Yuan, Zhihan,Zhou, Yirong,Yang, Qin,Xie, Yepeng,Deng, Zhihong,Peng, Yiyuan
supporting information, p. 1956 - 1962 (2016/11/24)
A series of 2,4-diarylquinazolines have been successfully synthesized via the Ni-catalyzed cross-coupling reaction of quinazoline-4-tosylates and aryl Grignard reagents, which provided alternative straightforward approaches for the introduction of aryl groups to quinazolines at C-4 position.
