845729-43-3 Usage
Description
4-(3-nitrophenyl)-3-Morpholinone is an organic compound that serves as an impurity in Rivaroxaban (R538000), a novel antithrombotic agent. It is characterized by the presence of a nitrophenyl group and a morpholinone moiety, which contribute to its chemical properties and potential applications.
Uses
Used in Pharmaceutical Industry:
4-(3-nitrophenyl)-3-Morpholinone is used as an impurity in the production of Rivaroxaban, a highly potent and selective direct FXa inhibitor. 4-(3-nitrophenyl)-3-Morpholinone plays a role in the development and formulation of antithrombotic drugs, which are essential for preventing blood clots and treating related conditions.
In the pharmaceutical industry, the presence of impurities like 4-(3-nitrophenyl)-3-Morpholinone is crucial for ensuring the safety, efficacy, and quality of the final drug product. Rigorous testing and control measures are implemented to manage and minimize the impact of these impurities on the overall performance of the medication.
Check Digit Verification of cas no
The CAS Registry Mumber 845729-43-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,5,7,2 and 9 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 845729-43:
(8*8)+(7*4)+(6*5)+(5*7)+(4*2)+(3*9)+(2*4)+(1*3)=203
203 % 10 = 3
So 845729-43-3 is a valid CAS Registry Number.
845729-43-3Relevant articles and documents
A Facile Oxidation of Tertiary Amines to Lactams by Using Sodium Chlorite: Process Improvement by Precise pH Adjustment with CO 2
Liu, Chaoyang,Sun, Haozhou,Qin, Cheng,Yang, Tiannuo,Zhang, Wenxian,Zhou, Yuan,Li, Yani,Jia, Zheng Robert,Chu, Changhu
, p. 993 - 997 (2022/05/17)
By using cheap and innocuous sodium chlorite, a series of tertiary amines have been oxidized to the corresponding lactams with good selectivity and high yield. In this method, neither transition-metal catalyst nor oxidant was used. In the oxidation step, the pH of the sodium chlorite was precisely adjusted to pH around 6 using CO2, such pH is a compromise between oxidative properties, chemical stability, and unwanted precipitation. In addition, buffer salts are not necessary, which allows this oxidation reaction to be performed under safe and environmentally benign conditions.
