845729-43-3

Basic information

• Product Name: 4-(3-nitrophenyl)-3-Morpholinone
• Synonyms: 4-(3-nitrophenyl)-3-Morpholinone;Rivaroxaban Impurity 66
• CAS NO: 845729-43-3
• Molecular Formula: C10H10N2O4
• Molecular Weight: 222.1974
• Mol File: 845729-43-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 491.2±40.0 °C(Predicted)
• Appearance: /
• Density: 1.379±0.06 g/cm3(Predicted)
• PKA: -2.20±0.20(Predicted)
• CAS DataBase Reference: 4-(3-nitrophenyl)-3-Morpholinone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-nitrophenyl)-3-Morpholinone(845729-43-3)
• EPA Substance Registry System: 4-(3-nitrophenyl)-3-Morpholinone(845729-43-3)

Safety Data

• Hazardous Substances Data: 845729-43-3(Hazardous Substances Data)

Usage

Uses

4-(3-Nitrophenyl)-3-morpholinone is an impurity of Rivaroxaban (R538000) which is a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.

Upstream product

• 402-67-5 3-fluoro-1-nitrobenzene 

Relevant articles and documents

A Facile Oxidation of Tertiary Amines to Lactams by Using Sodium Chlorite: Process Improvement by Precise pH Adjustment with CO 2

By using cheap and innocuous sodium chlorite, a series of tertiary amines have been oxidized to the corresponding lactams with good selectivity and high yield. In this method, neither transition-metal catalyst nor oxidant was used. In the oxidation step, the pH of the sodium chlorite was precisely adjusted to pH around 6 using CO2, such pH is a compromise between oxidative properties, chemical stability, and unwanted precipitation. In addition, buffer salts are not necessary, which allows this oxidation reaction to be performed under safe and environmentally benign conditions.