845780-53-2Relevant academic research and scientific papers
Total synthesis of thuggacin B
Bock, Martin,Dehn, Richard,Kirschning, Andreas
supporting information; experimental part, p. 9134 - 9137 (2009/02/08)
Final proof of the complete structures of thuggacins A-C was gained by a highly convergent and flexible total synthesis. Notable features include a substrate-controlled, titanium-mediated aldol reaction, a cross-metathesis approach for converting terminal alkenes into the corresponding vinyl iodides, and the cross-coupling of a complex vinyl iodide and terminal alkyne in the Sonogashira reaction. (Chemical Equation Presented).
Ring-closing metathesis approach to dictyostatin
Kangani, Cyrous O.,Brueckner, Arndt M.,Curran, Dennis P.
, p. 379 - 382 (2007/10/03)
(Chemical Equation Presented) An esterification/ring-closing metathesis approach to dictyostatin and discodermolide is introduced. The approach provides for facile fragment coupling of two main segments of these natural products at the C10-C11 alkene with
