845781-34-2

Basic information

• Product Name: 5-(3-METHOXYPHENYL)-5-OXOVALERIC ACID
• Synonyms: 5-(3-METHOXYPHENYL)-5-OXOVALERIC ACID
• CAS NO: 845781-34-2
• Molecular Formula: C₁₂H₁₄O₄
• Molecular Weight: 222.24
• Mol File: 845781-34-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 84-88°C
• Boiling Point: 411.4°C at 760 mmHg
• Flash Point: 159.8°C
• Appearance: /
• Density: 1.175g/cm³
• Vapor Pressure: 1.67E-07mmHg at 25°C
• Refractive Index: 1.53
• CAS DataBase Reference: 5-(3-METHOXYPHENYL)-5-OXOVALERIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-METHOXYPHENYL)-5-OXOVALERIC ACID(845781-34-2)
• EPA Substance Registry System: 5-(3-METHOXYPHENYL)-5-OXOVALERIC ACID(845781-34-2)

Safety Data

• Hazardous Substances Data: 845781-34-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H14O4/c1-16-10-5-2-4-9(8-10)11(13)6-3-7-12(14)15/h2,4-5,8H,3,6-7H2,1H3,(H,14,15)

Upstream product

• 108-55-4 glutaric anhydride, 
• 2398-37-0 3-methoxyphenyl bromide 
• 36282-40-3 (3-methoxyphenyl)magnesium bromide 

Downstream Products

• 6500-64-7 5-(3'-methoxyphenyl)pentanoic acid 
• 6500-65-8 2-methoxy-6,7,8,9-tetrahydro-benzocyclohepten-5-one 
• 1270299-87-0 (+)-(R)-δ-(3-methoxyphenyl)-δ-valerolactone 
• 461389-46-8 6-(3-methoxyphenyl)-1-methyl-2-piperidone 
• 461389-49-1 2-(3-methoxyphenyl)-1-methylpiperidine 
• 461389-54-8 2-(3-hydroxyphenyl)-1-methylpiperidine 
• 461389-44-6 6-(3-methoxyphenyl)-2-piperidone 

Relevant articles and documents

Stereoselective synthesis of lower and upper rim functionalized tetra-α isomers of calix[4]pyrroles

Hydroxyaryl alkyl ketones with functionalized alkyl chains often fail to produce the corresponding tetra-α calix[4]pyrroles in Br?nsted acid mediated condensations with pyrrole. A remarkable effect exerted by the addition of methyltrialkylammonium chloride during the acid-mediated syntheses of a series of meso-(tetrahydroxyaryl)-meso-tetraalkylcalix[4]- pyrroles featuring alkyl terminal chloro or ester groups is reported. The ammonium salt enhances the cyclocondensation reaction and induces the almost exclusive formation of the tetra-α isomers.

A 2 - methoxy - 6, 7, 8, 9 - tetrahydrobenz cyclohepta - 5 - ketone (by machine translation)

The invention discloses a method for synthesizing 2 - methoxy - 6, 7, 8, 9 - tetrahydrobenz cyclohepta - 5 - one method, its steps are: halogen anisole with glutaric anhydride reaction for the preparation of 5 - (3 - methoxyphenyl) - 5 - oxo-valeric acid, reducing 5 - (3 - methoxyphenyl) - 5 - oxo-valeric acid for the preparation of 5 - (3 - methoxyphenyl) pentanoic acid; 5 - (3 - methoxyphenyl) pentanoic acid through the intramolecular Friedel-crafts acylation reaction to obtain 2 - methoxy - 6, 7, 8, 9 - tetrahydrobenz cyclohepta - 5 - one. The method of the invention the synthesis step is short, low cost, the total yield is high, can be used for industrial production. (by machine translation)

Synthesis and cholinesterase activity of phenylcarbamates related to Rivastigmine, a therapeutic agent for Alzheimer's disease

In order to develop new cholinesterase agents effective against Alzheimer's disease (AD) we synthesized some phenylcarbamates structurally related to Rivastigmine and evaluated their in vitro and in vivo biological activity. Among the compounds which displayed the most significant in vitro activity, 1-[1-(3-dimethylcarbamoyloxyphenyl)ethyl]piperidine (31b), in addition to a simple and cheaper synthesis, showed lower toxicity and very similar therapeutic index in comparison with Rivastigmine.