845821-98-9

Basic information

• Product Name: Methanone, bis[2-[bis(3,5-dimethylphenyl)phosphino]phenyl]-
• CAS NO: 845821-98-9
• Molecular Formula: C45H44OP2
• Molecular Weight: 662.791
• Mol File: 845821-98-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Methanone, bis[2-[bis(3,5-dimethylphenyl)phosphino]phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, bis[2-[bis(3,5-dimethylphenyl)phosphino]phenyl]-(845821-98-9)
• EPA Substance Registry System: Methanone, bis[2-[bis(3,5-dimethylphenyl)phosphino]phenyl]-(845821-98-9)

Safety Data

• Hazardous Substances Data: 845821-98-9(Hazardous Substances Data)

Upstream product

• 135-02-4 ortho-anisaldehyde 
• 77464-21-2 2-methoxy-α-(2-methoxyphenyl)benzenemethanol 
• 845821-95-6 bis(2-trifluoromethylsulfonyloxyphenyl)methanone 
• 578-57-4 2-bromoanisole 
• 835-11-0 2,2'-dihydroxybenzophenone 
• 13102-33-5 2,2'-dimethoxybenzophenone 
• 187344-92-9 bis(3,5-dimethylphenyl)phosphine oxide 

Relevant articles and documents

Complete chiral induction from enantiopure 1,2-diamines to benzophenone-based achiral bisphosphane ligands in noyori-type RuII catalysts

We report the design and synthesis of a novel class of RuII catalysts (3) composed of achiral benzophenone-based bisphosphane ligands and enantiopure 1,2-diamines for the asymmetric hydrogenation of aryl ketones. The developed catalysts show excellent enantioselectivities (up to 97 % ee) and activities (up to S/C = 10,000) in the hydrogenation of a variety of aromatic ketones. Complete chiral induction from the enantiopure 1,2-diamine to the achiral bisphosphane ligand was observed. The coordination of the C=O moiety in 3 to the cationic RuII center is considered to be of key importance in providing a higher thermodynamic and kinetic rotation barrier for the flexible bisphosphane ligand, resulting in the preferential formation of only one diastereomer, and thus explaining the high enantioselectivity of the catalyst. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.