84585-79-5Relevant academic research and scientific papers
Intramolecular Influence of a Carboxylic Function on Platinium Blue Synthesis. A systematic Study of Complexes Originating from Acid Amides
Arrizabalaga, Philippe,Castan, Paule,Laurent, Jean-Pierre
, p. 4814 - 4818 (2007/10/02)
The use of acid amide as ligand for obtaining platinium blue has been investigated.While blue compounds are generally obtained by using the hydrolysis product of cis-dichlorodiammineplatinum(II) as platinum surce, with such ligands the reaction occurs very readily using potassium tetrachloroplatinate(II).The role of the carboxylic function which offers here a primary ligating site to platinum is evidenced.The compounds obtained have been characterized by UV-visible spectral measurments, Ce(IV) oxydative titration , ESR spectroscopy, and magnetic properties.Antitumoral activity toward leukemia L1210 and sarcoma 180 is reported for two of thesecompounds.As a first step for this antitumor study, these compounds have been found to be inactive toward Leukemia while they presnt intersting activity toward Sarcoma.
Synthesis of &γ-Aminobutyric Acid Analogue of Restricted Conformation. Part 1. The 2-(Aminomethyl)cycloalkaneacetic Acids
Kennewell, Peter D.,Matharu, Saroop S.,Taylor, John B.,Westwood, Robert,Sammes, Peter G.
, p. 2563 - 2570 (2007/10/02)
The synthesis of analogues with restricted rotatin about the C(2)-C(3) bond of γ-aminobutyric acid, namely cis- and trans-2-(aminomethyl)-cyclopropane and -cyclobutanecarboxylic acids and trans-2-(aminomethyl)cyclohexanecarboxylic acid are described.
