845866-52-6 Usage
Uses
Used in Pharmaceutical Industry:
3-(4-Fluorobenzyloxy)-bromobenzene is used as a building block for the development of new pharmaceuticals due to its unique structure that can be further modified to create a variety of medicinal compounds. Its presence in the synthesis process can contribute to the discovery of novel drugs with improved therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 3-(4-Fluorobenzyloxy)-bromobenzene is utilized as a precursor for the synthesis of agrochemicals, such as pesticides and herbicides. Its chemical properties allow for the creation of compounds that can effectively control pests and weeds, thereby enhancing crop protection and yield.
Used in Specialty Chemicals Production:
3-(4-Fluorobenzyloxy)-bromobenzene is employed as a key component in the production of specialty chemicals, which are used in various industries such as plastics, coatings, and fragrances. Its unique characteristics enable the creation of high-performance materials with specific properties tailored to the needs of these industries.
Used as a Reagent in Chemical Reactions:
3-(4-FLUOROBENZYLOXY)-BROMOBENZENE serves as a reagent in a variety of chemical reactions, facilitating the synthesis of other complex organic compounds. Its reactivity and stability make it a reliable choice for researchers and chemists working on the development of new chemical entities.
Used as a Research Tool in Organic Chemistry:
3-(4-Fluorobenzyloxy)-bromobenzene is also used as a research tool in the field of organic chemistry, aiding scientists in understanding reaction mechanisms, exploring new synthetic routes, and advancing the knowledge of organic compounds and their applications.
Check Digit Verification of cas no
The CAS Registry Mumber 845866-52-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,5,8,6 and 6 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 845866-52:
(8*8)+(7*4)+(6*5)+(5*8)+(4*6)+(3*6)+(2*5)+(1*2)=216
216 % 10 = 6
So 845866-52-6 is a valid CAS Registry Number.
845866-52-6Relevant academic research and scientific papers
Lan, Jin-Shuai,Zhang, Tong,Liu, Yun,Zhang, Yong,Hou, Jian-wei,Xie, Sai-Sai,Yang, Jing,Ding, Yue,Cai, Zhen-zhen
, p. 471 - 478 (2017)
A new series of small molecules bearing a benzyloxy substituent have been designed, synthesized and evaluated for hMAO inhibitory activity in vitro. Most of the compounds were potent and selective MAO-B inhibitors, and were weak inhibitors of MAO-A. In particular, compounds 9e (IC50 = 0.35 μM) and 10e (IC50 = 0.19 μM) were the most potent MAO-B inhibitors, and exhibited the highest selectivity for MAO-B (9e, SI > 285.7-fold and 10e, SI = 146.8-fold). In addition, the structure-activity relationships for MAO-B inhibition indicated that electron-withdrawing groups in the open small molecules were more suitable for MAO-B inhibition, and substitutions at the benzyloxy of the open small molecules, particularly with the halogen substituted benzyloxy, were more favorable for MAO-B inhibition. Molecular docking studies have been done to explain the potent MAO-B inhibition of the open small molecules. Furthermore, the representative compounds 9e and 10e showed low neurotoxicity in SH-SY5Y cells in vitro. So the small molecules bearing the benzyloxy substituent could be used to develop promising drug candidates for the therapy of neurodegenerative diseases.
