84598-97-0Relevant academic research and scientific papers
Synthesis of 5,6,7-trinor-4,8-inter-m-phenylene PGI2 and Beraprost
Wakita, Hisanori,Matsumoto, Kazuhisa,Yoshiwara, Hideo,Hosono, Yutaka,Hayashi, Ryoji,Nishiyama, Hisao,Nagase, Hiroshi
, p. 2449 - 2474 (1999)
We have disclosed a new class of stable PGI2 analogue, 5,6,7-trinor- 4,8-inter-m-phenylene PGI2 which has a phenyl ether moiety instead of enol- ether skeleton in PGI2. The m-phenylene PGI2 and its derivative (Betaprost) were synthesized via dihydrocyclopenta[b]benzofuran derivatives as key intermediates by ortho-selective metal-halogen exchange reaction with Grignard reagents and subsequent copper-catalyzed cyclization. The ω-side chains were introduced by stereoselective epoxide formation or Prins reaction.
Allylic substitution of meso-1,4-diacetoxycycloalkenes in water with an amphiphilic resin-supported chiral palladium complex
Uozumi, Yasuhiro,Takenaka, Hiroe,Suzuka, Toshimasa
experimental part, p. 1557 - 1561 (2009/04/07)
Asymmetric π-allylic substitution of meso-1,4-diacet-oxycyclopentene and meso-1,4-diacetoxycyclohexene with various nucleophiles was performed with an amphiphilic polystyrene-polyethylene glycol) (PS-PEG) resin-supported chiral imidazoin-dolephosphine-palladium complex in water as a single reaction medium under heterogeneous conditions to give the corresponding 1-acetoxy-4-substituted cycloalkenes with up to 99% ee.
